2-CHLORO-2-PHENYLACETAMIDE

Base Information

• Chemical Name: 2-CHLORO-2-PHENYLACETAMIDE
• CAS No.: 7462-76-2
• Molecular Formula: C8H8 Cl N O
• Molecular Weight: 169.611
• Hs Code.: 2924299090
• Mol file: 7462-76-2.mol

Synonyms:Acetamide, 2-chloro-2-phenyl- (6CI,7CI,8CI);2-Chloro-2-phenylacetamide; NSC 402157

Chemical Property of 2-CHLORO-2-PHENYLACETAMIDE

Chemical Property:

• Vapor Pressure: 0.000193mmHg at 25°C
• Boiling Point: 328.2°Cat760mmHg
• Flash Point: 152.3°C
• PSA: 43.09000
• Density: 1.254g/cm³
• LogP: 2.15210

Purity/Quality:

99% ^*data from raw suppliers

2-chloro-2-phenylacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLORO-2-PHENYLACETAMIDE

There total 14 articles about 2-CHLORO-2-PHENYLACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

α-chlorophenylacetyl chloride (2912-62-1) → 2-chloro-2-phenylacetamide (7462-76-2)

Guidance literature:

With ammonia; In water; at 25 ℃; for 0.5h;

DOI:10.1039/d0ra04359a

Reference yield: 78.0%

→ 2-chloro-2-phenylacetamide (7462-76-2) + 4-methoxy-benzaldehyde (123-11-5)

Guidance literature:

With dipotassium peroxodisulfate; tris(2,2'-bipyridyl)ruthenium dichloride; In water; acetonitrile; at 20 ℃; for 12h; Irradiation;

Reference yield: 78.0%

2-chloro-N-(4-methoxybenzyl)-2-phenylethanamide (401582-20-5) → 2-chloro-2-phenylacetamide (7462-76-2)

Guidance literature:

With dipotassium peroxodisulfate; tris(bipyridine)ruthenium(II) dichloride hexahydrate; water; In acetonitrile; at 20 ℃; for 12h; Sealed tube; Irradiation; Green chemistry;

DOI:10.1002/adsc.201500257

upstream raw materials:

2-chloro-2-phenylacetonitrile

(RS)-mandelamide

4-phenyl-pyrrolidine-2,3,5-trione

water

Refernces

• 1、 -. "METHOD OF FORMING CARBONYL COMPOUND AND DEPROTECTION METHOD OF AMIDE-BASED COMPOUND USING A CLEAVAGE REACTION OF CARBON-NITROGEN BOND". Paragraph 0092; 0093; 0101; 0102; 0103. . Retrieved 2016/11/24.
• 2、 Van Pelt,Zhang,Otten,Holt,Sorokin,Van Rantwijk,Black,Perry,Sheldon. "Probing the enantioselectivity of a diverse group of purified cobalt-centred nitrile hydratases". experimental part. p. 3011 - 3019. Retrieved 2011/06/17.