3-Hydrazino-6-(4-methoxyphenyl)pyridazine

Base Information

• Chemical Name: 3-Hydrazino-6-(4-methoxyphenyl)pyridazine
• CAS No.: 18772-76-4
• Molecular Formula: C11H12N4O
• Molecular Weight: 216.242
• Hs Code.: 2933990090
• ChEMBL ID: CHEMBL3763865
• DSSTox Substance ID: DTXSID50577853
• Wikidata: Q82467971
• Mol file: 18772-76-4.mol

Synonyms:18772-76-4;3-Hydrazino-6-(4-methoxyphenyl)pyridazine;3-(p-Anisyl)-6-hydrazinopyridazine;3-hydrazinyl-6-(4-methoxyphenyl)pyridazine;[6-(4-methoxyphenyl)pyridazin-3-yl]hydrazine;SCHEMBL2886895;CHEMBL3763865;DTXSID50577853;ASGDUFOXUMFAMV-UHFFFAOYSA-N;AKOS005602216;3-hydrazino-6(4-methoxyphenyl)-pyridazine

Chemical Property of 3-Hydrazino-6-(4-methoxyphenyl)pyridazine

Chemical Property:

• Boiling Point: 476.3 °C at 760 mmHg
• Flash Point: 241.9 °C
• PSA: 73.06000
• Density: 1.258 g/cm³
• LogP: 2.21110
• Storage Temp.: Refrigerator
• Solubility.: DMSO, Methanol
• XLogP3: 1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 216.10111102
• Heavy Atom Count: 16
• Complexity: 206

Purity/Quality:

98%Min ^*data from raw suppliers

3-(p-Anisyl)-6-hydrazinopyridazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2=NN=C(C=C2)NN
• Uses: An Intermediate for the synthesis of the drug Gabazine.

Technology Process of 3-Hydrazino-6-(4-methoxyphenyl)pyridazine

There total 3 articles about 3-Hydrazino-6-(4-methoxyphenyl)pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-chloro-6-(4-methoxyphenyl)pyridazine (58059-31-7) → 3-hydrazino-6-(p-methoxyphenyl)pyridazine (18772-76-4)

Guidance literature:

With hydrazine hydrate; In butan-1-ol; at 100 ℃; for 6h;

DOI:10.1021/jm00385a003

Reference yield:

6-(4-methoxyphenyl)-2H-pyridazin-3-one (2166-33-8) → 3-hydrazino-6-(p-methoxyphenyl)pyridazine (18772-76-4)

Guidance literature:

Multi-step reaction with 2 steps

1: phosphorus oxychloride / 4 h / 85 - 95 °C

2: hydrazine hydrate / butan-1-ol / 6 h / 100 °C

With hydrazine hydrate; trichlorophosphate; In butan-1-ol;

DOI:10.1021/jm00385a003

Reference yield:

→ 3-hydrazino-6-(p-methoxyphenyl)pyridazine (18772-76-4)

Guidance literature:

6-Chlorpyridazin (XV), N2H4;

upstream raw materials:

3-chloro-6-(4-methoxyphenyl)pyridazine

6-(4-methoxyphenyl)-2H-pyridazin-3-one

Downstream raw materials:

2-(3-carboxypropyl)-3-amino-6-(4-methoxyphenyl)pyridazinium bromide

6-Amino-1-(3-ethoxycarbonyl-propyl)-3-(4-methoxy-phenyl)-pyridazin-1-ium; bromide

ethyl 6-(4-methoxyphenyl)[1,2,4]triazolo[4,3-b]pyridazine-3-carboxylate

3-amino-6-(4'-methoxyphenyl)pyridazine

Refernces