2-(1,3-dimethyl-2,6-dioxo-purin-7-yl)acetic acid

Base Information

• Chemical Name: 2-(1,3-dimethyl-2,6-dioxo-purin-7-yl)acetic acid
• CAS No.: 96989-76-3
• Molecular Formula: C13H18Br2N2O^.C9H10N4O4
• Molecular Weight: 616.31
• Mol file: 96989-76-3.mol

Synonyms:Acebrophylline;1,2,3,6-Tetrahydro-1,3-dimethyl-2,6-dioxo-7H-purine-7-acetic acid with trans-4-[[(2-Amino-3,5-dibromophenyl)methyl]amino]cyclohexanol;

Chemical Property of 2-(1,3-dimethyl-2,6-dioxo-purin-7-yl)acetic acid

Chemical Property:

• Vapor Pressure: 1.38E-09mmHg at 25°C
• Boiling Point: 468.6 °C at 760 mmHg
• Flash Point: 237.2 °C
• PSA: 99.12000
• LogP: -1.48170
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Sparingly), Methanol (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

Acebrophylline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Acebrophylline can be utilized for adverse effect, pharmacological activity and biological study of effect of acebrophylline vs. sustained release theophylline in patients of chronic obstructive pulmonary disease

Technology Process of 2-(1,3-dimethyl-2,6-dioxo-purin-7-yl)acetic acid

There total 1 articles about 2-(1,3-dimethyl-2,6-dioxo-purin-7-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.2%

ambroxol (18683-91-5,36557-04-7,107814-37-9) + acefylline (652-37-9) → 1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo-7H-purine-7-acetic acid trans-4-[[(2-amino-3,5-dibromophenyl)methyl]amino]cyclohexanol (96989-76-3,179118-73-1)

Guidance literature:

ambroxol; In toluene; at 60 - 65 ℃; for 0.0166667h;

acefylline; In toluene; at 75 - 105 ℃; for 0.45 - 0.55h; Temperature; Solvent; Time;

upstream raw materials:

ambroxol

acefylline

Refernces