Technology Process of (3aS,8aR)-5-methoxy-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole
There total 210 articles about (3aS,8aR)-5-methoxy-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
formaldehyd; (3aS,8aR)-5-methoxy-3a,8-dimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole;
In
methanol; water;
at 0 ℃;
for 0.0833333h;
Inert atmosphere;
With
sodium tris(acetoxy)borohydride;
In
methanol; water;
at 20 ℃;
for 1.5h;
Inert atmosphere;
- Guidance literature:
-
methylamine hydrochloride; (3S)-(5-methoxy-1,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-3-yl)acetaldehyde;
With
magnesium sulfate;
In
tetrahydrofuran;
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
DOI:10.1021/ja046690e
- Guidance literature:
-
methylamine hydrochloride; 2-(5-methoxy-1,3-dimethyl-2-oxoindolin-3-yl)acetaldehyde;
With
magnesium sulfate; triethylamine;
In
tetrahydrofuran;
at 20 ℃;
for 16h;
Inert atmosphere;
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 80 ℃;
for 1.5h;
DOI:10.1021/ol500033w
