(1E)-1-Benzylidene-2-(2-chlorophenyl)hydrazine

Base Information

• Chemical Name: (1E)-1-Benzylidene-2-(2-chlorophenyl)hydrazine
• CAS No.: 2989-40-4
• Molecular Formula: C13H11 Cl N2
• Molecular Weight: 230.697
• NSC Number: 74683
• Mol file: 2989-40-4.mol

Synonyms:2989-40-4;(1E)-1-Benzylidene-2-(2-chlorophenyl)hydrazine;NSC74683;NSC-74683

Chemical Property of (1E)-1-Benzylidene-2-(2-chlorophenyl)hydrazine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 351.1°Cat760mmHg
• Flash Point: 166.1°C
• Density: 1.13g/cm³
• XLogP3: 4.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 230.0610761
• Heavy Atom Count: 16
• Complexity: 224

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C=NNC2=CC=CC=C2Cl
• Isomeric SMILES: C1=CC=C(C=C1)/C=N/NC2=CC=CC=C2Cl

Technology Process of (1E)-1-Benzylidene-2-(2-chlorophenyl)hydrazine

There total 4 articles about (1E)-1-Benzylidene-2-(2-chlorophenyl)hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

benzaldehyde (100-52-7) + (2-chlorophenyl)hydrazine (10449-07-7) → 1-benzylidene-2-(2-chlorophenyl)hydrazine (2989-40-4)

Guidance literature:

In ethanol; water; at 20 ℃; Darkness;

DOI:10.1016/j.ejmech.2017.09.037

Reference yield:

benzyl chloride (100-44-7) → 1-benzylidene-2-(2-chlorophenyl)hydrazine (2989-40-4)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol

2: mercury (II)-oxide; chloroform

With ethanol; chloroform; mercury(II) oxide;

Reference yield:

(2-chlorophenyl)hydrazine (10449-07-7) → 1-benzylidene-2-(2-chlorophenyl)hydrazine (2989-40-4)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol

2: mercury (II)-oxide; chloroform

With ethanol; chloroform; mercury(II) oxide;

upstream raw materials:

N-benzyl-N-(2-chlorophenyl)hydrazine

benzyl chloride

(2-chlorophenyl)hydrazine

benzaldehyde

Downstream raw materials:

1(5)-phenyl>-3-phenyl-5(1)-(o-chlorophenyl)formazan

N'-(2-chlorophenyl)benzohydrazonoyl chloride

2-chloro-benzaldehyde

N-(2-chloro-phenyl)-3,N'''-diphenyl-formazan

Refernces

• 1、 Jia, Tingting,Liu, Shourong,Shao, Jiaan,Shi, Tao,Wu, Zhaoxiao,Zeng, Linghui,Zhang, Chong,Zhang, Jiankang,Zhu, Huajian,Zhuang, Rangxiao. "Sequential [3+2] annulation reaction of prop-2-ynylsulfonium salts and hydrazonyl chlorides: Synthesis of pyrazoles containing functional motifs". supporting information. p. 8460 - 8463. Retrieved 2021/09/08.
• 2、 Ribeiro, Carlos J.A.,Nunes, Rute C.,Amaral, Joana D.,Gon?alves, Lídia M.,Rodrigues, Cecília M.P.,Moreira, Rui,Santos, Maria M.M.. "Spirotriazoline oxindoles: A novel chemical scaffold with in vitro anticancer properties". . p. 494 - 509. Retrieved 2017/10/10.