2-Hydrazinyl-4-methylthiazole hydrochloride

Base Information

• Chemical Name: 2-Hydrazinyl-4-methylthiazole hydrochloride
• CAS No.: 78886-45-0
• Molecular Formula: C₄H₇N₃S
• Molecular Weight: 129.186
• Hs Code.: 2934100090
• European Community (EC) Number: 801-007-9,830-236-7
• NSC Number: 372681
• Mol file: 78886-45-0.mol

Synonyms:14397-08-1;2-Hydrazinyl-4-methylthiazole hydrochloride;(4-Methyl-thiazol-2-yl)-hydrazine hydrochloride;2-Hydrazino-4-methyl-1,3-thiazole hydrochloride;2-hydrazinyl-4-methyl-1,3-thiazole hydrochloride;(4-methyl-1,3-thiazol-2-yl)hydrazine;hydrochloride;(4-Methyl-thiazol-2-yl)-hydrazine HCl;SCHEMBL7036884;PJVVBMWIMGMGGP-UHFFFAOYSA-N;MFCD07290056;NSC372681;AKOS015907756;NSC-372681;SB33641;2-Hydrazinyl-4-methylthiazolehydrochloride;BS-35721;2-hydrazino-4-methylthiazole hydrochloride;CS-0205535;EN300-11724;F87123;Z57980667;Thiazole, 2-hydrazinyl-4-methyl-, hydrochloride (1:1);2-(4-METHOXYPHENYL)-4-METHYL-1,3-THIAZOLE-5-CARBOXYLICACID

Chemical Property of 2-Hydrazinyl-4-methylthiazole hydrochloride

Chemical Property:

• Vapor Pressure: 0.0137mmHg at 25°C
• Melting Point: 102 °C
• Boiling Point: 258.5°Cat760mmHg
• PKA: 0.69±0.40(Predicted)
• Flash Point: 110.2°C
• PSA: 79.18000
• Density: 1.359g/cm³
• LogP: 1.51040
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 165.0127461
• Heavy Atom Count: 9
• Complexity: 77.7

Purity/Quality:

97% ^*data from raw suppliers

(4-Methyl-thiazol-2-yl)-hydrazine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CSC(=N1)NN.Cl

Technology Process of 2-Hydrazinyl-4-methylthiazole hydrochloride

There total 4 articles about 2-Hydrazinyl-4-methylthiazole hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

thiosemicarbazone of acetone → 2-hydrazino-4-methyl-thiazole (78886-45-0)

Guidance literature:

With 1-bromoacetone; In chloroform; for 6h; Ambient temperature;

Reference yield:

thiosemicarbazide (79-19-6) → 2-hydrazino-4-methyl-thiazole (78886-45-0)

Guidance literature:

In isopropyl alcohol; for 0.333333h; Reflux;

DOI:10.1016/j.bmc.2016.01.028

Reference yield:

3,4,5-Trimethoxy-benzoic acid N'-(4-methyl-thiazol-2-yl)-hydrazide (146942-59-8) → 2-hydrazino-4-methyl-thiazole (78886-45-0)

Guidance literature:

With sodium hydroxide; In ethanol; for 2h; Heating;

upstream raw materials:

2-(2-acetylhydrazino)-4-methylthiazole

3,4,5-Trimethoxy-benzoic acid N'-(4-methyl-thiazol-2-yl)-hydrazide

thiosemicarbazide

Downstream raw materials:

2-benzylidenehydrazono-4-methylthiazole

Refernces

• 1、 Heravi,Bakavoli,Shafaie,Mir Mohammad Sadeghi,Khoshdast. "Palladium-catalyzed cyclization of 3-propargylmercapto-1,2,4-triazine to thiazolo[2,3-c][1,2,4]triazine". . p. 1260 - 1262. Retrieved 2007/10/03.