N-phenylacetohydrazide

Base Information

• Chemical Name: N-phenylacetohydrazide
• CAS No.: 2116-41-8
• Molecular Formula: C8H10N2O
• Molecular Weight: 150.18
• Mol file: 2116-41-8.mol

Synonyms:

Chemical Property of N-phenylacetohydrazide

Chemical Property:

• Vapor Pressure: 0.0144mmHg at 25°C
• Boiling Point: 257.6°Cat760mmHg
• Flash Point: 109.6°C
• Density: 1.171g/cm³

Purity/Quality:

90%,98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of N-phenylacetohydrazide

There total 26 articles about N-phenylacetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

acetyl chloride (75-36-5) + phenylhydrazine (100-63-0) → 1-Acetyl-1-phenylhydrazin (2116-41-8)

Guidance literature:

phenylhydrazine; With di-tert-butyl dicarbonate; In dichloromethane; at 0 ℃; for 1h;

acetyl chloride; With triethylamine; In dichloromethane; at 25 ℃; for 4h;

With trifluoroacetic acid; at 0 ℃;

DOI:10.1021/acs.orglett.6b00949

Reference yield: 52.0%

1-tert-butoxycarbonyl-2-acetyl-2-phenylhydrazine → 1-Acetyl-1-phenylhydrazin (2116-41-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; Inert atmosphere; Cooling with ice;

DOI:10.1021/jacs.6b04532

Reference yield:

4-(acetyl-phenyl-hydrazonomethyl)-benzoic acid → 4-Carboxybenzaldehyde (619-66-9) + 1-Acetyl-1-phenylhydrazin (2116-41-8)

Guidance literature:

In phosphate buffer; water-d2; pH=7; Equilibrium constant;

DOI:10.1039/b211645f

upstream raw materials:

pyridine

N-acetylpropionamide

phenylhydrazine hydrochloride

N'-acetyl-N'-phenylacetohydrazide

Downstream raw materials:

acetic acid-[(2-oxo-indolin-3-ylidene)-phenyl-hydrazide]

5-methyl-1,4-diphenyl-1,2,4-triazolinum-3-thiolate

1-(N-acetyl-anilino)-3,3-diphenyl-azetidine-2,4-dione

1-(N-acetyl-anilino)-3,3-diethyl-azetidine-2,4-dione

Refernces

• 1、 Zhou, Shuguang,Wang, Jinhu,Zhang, Feifei,Song, Chao,Zhu, Jin. "A Versatile, Traceless C-H Activation-Based Approach for the Synthesis of Heterocycles". supporting information. p. 2427 - 2430. Retrieved 2016/06/09.
• 2、 Ali, Abdelselam,Fisara, Petr,Freemont, Jamie A.,Kyi, Stella,Meyer, Adam G.,Riches, Andrew G.,Sargent, Roger M.,Sawutz, David G.,Turner, Kathleen A.,Winzenberg, Kevin N.,Yang, Qi. "Discovery of ectoparasiticidal hydrazonotrifluoromethanesulfonanilides". experimental part. p. 649 - 652. Retrieved 2010/06/12.