Ataciguat

Base Information

• Chemical Name: Ataciguat
• CAS No.: 254877-67-3
• Molecular Formula: C₂₁H₁₉Cl₂N₃O₆S₃
• Molecular Weight: 576.502
• Mol file: 254877-67-3.mol

Synonyms:5-Chloro-2-((5-chloro-2-thienyl)sulfonylamino)-N-(4-(morpholin-4-ylsulfonyl)phenyl)benzamide;HMR 1766;UNII-QP166M390Q;5-Chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide;

Chemical Property of Ataciguat

Chemical Property:

• Refractive Index: 1.684
• PKA: 5.70±0.50(Predicted)
• PSA: 166.88000
• Density: 1.613 g/cm³
• LogP: 6.37440

Purity/Quality:

99% ^*data from raw suppliers

Ataciguat ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ataciguat, formerly referred to as HMR-1766, a novel anthranilic acid derivative, belongs to a new structural class of sGC activators capable of activating the oxidized form of sGC. Ataciguat has been shown to improve endothelial function and to reduce platelet activation in exptl. diabetes. Chronic regular treatment with sGC activators such as ataciguat could therefore eventually constitute an effective therapy targeting deficient NO/cGMP signaling in hypertension, peripheral and coronary artery disease, heart failure, thrombosis and erectile dysfunction.

Technology Process of Ataciguat

There total 1 articles about Ataciguat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Amino-5-chloro-N-(4-(morpholine-4-sulfonyl)-phenyl)-benzamide (254877-58-2) + 5-chlorothien-2-ylsulfonyl chloride (2766-74-7) → Ataciguat (254877-67-3)

Guidance literature:

upstream raw materials:

2-Amino-5-chloro-N-(4-(morpholine-4-sulfonyl)-phenyl)-benzamide

5-chlorothien-2-ylsulfonyl chloride

Refernces