Technology Process of dibenzo[b,f]thiepine-3-carboxylic acid 5,5-dioxide
There total 9 articles about dibenzo[b,f]thiepine-3-carboxylic acid 5,5-dioxide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydroxide;
In
ethanol;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1) sodium nitrite, aq. HCl 2) KI, CuI / 1) under 0 deg C 2) water, 2 h reflux
2: 100 percent / NaOH, CuI / H2O / 8 h / Heating
3: 99 percent / 1) lithium diisopropylamide / tetrahydrofuran; various solvent(s) / 1) -5 to -15 deg C, 40 min. 2) warming to 10 deg C, 3 h
4: 98 percent / polyphosphoric acid, water / 0.5 h / 140 °C
5: 97 percent / NaOH, NaBH4 / ethanol; H2O / 2 h / Ambient temperature
6: 86 percent / conc. H2SO4 / acetic acid / 1 h / 55 - 75 °C
7: 95 percent / sodium perborate tetrahydrate / acetic acid / 1 h / 60 - 115 °C
With
hydrogenchloride; sodium perborate; sodium hydroxide; sodium tetrahydroborate; copper(l) iodide; PPA; sulfuric acid; water; potassium iodide; lithium diisopropyl amide; sodium nitrite;
In
tetrahydrofuran; ethanol; water; acetic acid;
DOI:10.1002/jhet.5570230513
