(1-METHYL-1H-BENZOIMIDAZOL-2-YL)-METHANOL

Base Information

• Chemical Name: (1-METHYL-1H-BENZOIMIDAZOL-2-YL)-METHANOL
• CAS No.: 7467-35-8
• Molecular Formula: C9H10N2O
• Molecular Weight: 162.191
• Hs Code.: 2933990090
• Mol file: 7467-35-8.mol

Synonyms:2-Benzimidazolemethanol,1-methyl- (6CI,8CI);(1-Methyl-1H-benzimidazol-2-yl)methanol;1-Methyl-2-benzimidazolemethanol;1-Methyl-2-hydroxymethylbenzimidazole;NSC400948;(1-methyl-1H-benzimidazol-2-yl)methanol;1H-benzimidazole-2-methanol, 1-methyl-;

Chemical Property of (1-METHYL-1H-BENZOIMIDAZOL-2-YL)-METHANOL

Chemical Property:

• Vapor Pressure: 1.5E-05mmHg at 25°C
• Refractive Index: 1.622
• Boiling Point: 351.7 °C at 760 mmHg
• Flash Point: 166.5 °C
• PSA: 38.05000
• Density: 1.22 g/cm³
• LogP: 1.06560
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

1-Methyl-1H-benzimidazole-2-methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Methyl-1H-benzimidazole-2-methanol acts as a reagent in the synthesis, structure-activity relationship, antibacterial and antifungal activities of benzimidazoles. Design, synthesis and computational validation of novel benzimidazole/indole-based PPARα and PPARβ partial agonists.

Technology Process of (1-METHYL-1H-BENZOIMIDAZOL-2-YL)-METHANOL

There total 21 articles about (1-METHYL-1H-BENZOIMIDAZOL-2-YL)-METHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-methyl-2-formyl-1H-benzimidazole (3012-80-4) → (1-methyl-1H-benzimidazol-2-yl)methanol (7467-35-8)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; at 0 ℃; for 1.5h;

DOI:10.1002/anie.201310671

Reference yield: 96.0%

glycolic Acid (79-14-1) + N-methyl-1,2-phenylenediamine (4760-34-3) → (1-methyl-1H-benzimidazol-2-yl)methanol (7467-35-8)

Guidance literature:

With hydrogenchloride; In water; at 130 ℃; Sealed tube;

DOI:10.1016/j.bmcl.2019.01.020

Reference yield: 92.0%

2-(Hydroxymethyl)benzimidazole (4856-97-7) + methyl iodide (74-88-4) → (1-methyl-1H-benzimidazol-2-yl)methanol (7467-35-8)

Guidance literature:

With tetrabutylammomium bromide; potassium hydroxide; In tetrahydrofuran; at 0 ℃;

DOI:10.5012/bkcs.2013.34.4.1272

upstream raw materials:

2-(Hydroxymethyl)benzimidazole

dimethyl sulfate

methyl iodide

1-Methylbenzimidazole

Downstream raw materials:

2-benzoyloxymethyl-1-methyl-1H-benzoimidazole

2-chloromethyl-1-methyl-1H-benzimidazole

1-methyl-2-formyl-1H-benzimidazole

2-(bromomethyl)-1-methyl-1H-benzo[d]imidazolium bromide

Refernces

• 1、 Ding, Yangyang,Liu, Kai,Zhao, Xinyu,Lv, Yingtao,Yu, Rilei,Kang, Congmin. "Design, synthesis, and antitumor activity of novel benzoheterocycle derivatives as inhibitors of vascular endothelial growth factor receptor-2 tyrosine kinase". . p. 286 - 294. Retrieved 2020/01/28.
• 2、 White, Gemma V.,Edgar, Emma V.,Holmes, Duncan S.,Lewell, Xiao Qing,Liddle, John,Polyakova, Oxana,Smith, Kathrine J.,Thorpe, James H.,Walker, Ann L.,Wang, Yichen,Young, Robert J.,Hovnanian, Alain. "Kallikrein 5 inhibitors identified through structure based drug design in search for a treatment for Netherton Syndrome". . p. 821 - 825. Retrieved 2019/01/30.