1H-pyrrolo[3,2-h]quinoline-2-carboxylic acid

Base Information

• Chemical Name: 1H-pyrrolo[3,2-h]quinoline-2-carboxylic acid
• CAS No.: 58457-37-7
• Molecular Formula: C12H8N2O2
• Molecular Weight: 212.208
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID60207154
• Wikidata: Q83081048
• Mol file: 58457-37-7.mol

Synonyms:1H-pyrrolo[3,2-h]quinoline-2-carboxylic acid;58457-37-7;2-Carboxy-1H-pyrrolo(3,2-H)quinoline;1H-Pyrrolo(3,2-h)quinoline-2-carboxylic acid;1H-pyrrolo[3,2-h]quinoline-2-carboxylicacid;Oprea1_388270;CBDivE_007047;SCHEMBL23773230;DTXSID60207154;NKRJTXAQMCUSEC-UHFFFAOYSA-N;BBL028754;MFCD00552701;STK785977;AKOS004910887;CCG-125203;NCGC00342922-01;CS-0099229;EU-0066685;C75737;AB01334773-02;A869446;SR-01000388303;SR-01000388303-1

Chemical Property of 1H-pyrrolo[3,2-h]quinoline-2-carboxylic acid

Chemical Property:

• Vapor Pressure: 2.4E-12mmHg at 25°C
• Boiling Point: 536.6°Cat760mmHg
• Flash Point: 278.3°C
• PSA: 65.98000
• Density: 1.497g/cm³
• LogP: 2.41430
• Storage Temp.: 2-8°C
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 212.058577502
• Heavy Atom Count: 16
• Complexity: 295

Purity/Quality:

98%min ^*data from raw suppliers

1H-Pyrrolo[3,2-h]quinoline-2-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C3=C(C=C2)C=C(N3)C(=O)O)N=C1

Technology Process of 1H-pyrrolo[3,2-h]quinoline-2-carboxylic acid

There total 4 articles about 1H-pyrrolo[3,2-h]quinoline-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

8-hydrazino-quinoline dihydrochloride (91004-61-4) + 2-oxo-propionic acid (127-17-3) → 2-carboxy-1H-pyrrolo<3,2-h>quinoline (58457-37-7)

Guidance literature:

With sulfuric acid; acetic acid; Yield given. Multistep reaction; 1.) H₂O, 2.) reflux, 20 min;

Reference yield:

trans-N-(8-quinolinamino)-2-iminopropionic acid (58457-36-6) → 2-carboxy-1H-pyrrolo<3,2-h>quinoline (58457-37-7)

Guidance literature:

With hydrogenchloride;

DOI:10.1002/hlca.19530360506

Reference yield:

→ 2-carboxy-1H-pyrrolo<3,2-h>quinoline (58457-37-7)

Guidance literature:

With hydrogenchloride;

upstream raw materials:

trans-N-(8-quinolinamino)-2-iminopropionic acid

8-hydrazino-quinoline dihydrochloride

2-oxo-propionic acid

Downstream raw materials:

2-hydroxymethyl-1H-pyrrolo<3,2-h>quinoline

2-carbomethoxy-1H-pyrrolo<3,2-h>quinoline

1H-pyrrolo[3,2-h]quinoline

Refernces

• 1、 Grazia Ferlin,Chiarelotto,Baccichetti,Carlassare,Toniolo,Bordin. "2-Substituted 1H-pyrrolo [3,2-h] quinoline derivatives: Synthesis and aspects of their biological activity". . p. 1513 - 1528. Retrieved 2007/10/02.