TRANS-4-ACETAMIDOCYCLOHEXANOL

Base Information

• Chemical Name: TRANS-4-ACETAMIDOCYCLOHEXANOL
• CAS No.: 27489-60-7
• Molecular Formula: C8H15NO2
• Molecular Weight: 157.213
• Hs Code.: 2924299090
• Mol file: 27489-60-7.mol

Synonyms:Acetamide,N-(4-hydroxycyclohexyl)-, trans- (8CI);trans-4-Acetamidocyclohexanol;trans-N-Acetyl-4-hydroxycyclohexylamine;N-(4-hydroxycyclohexyl)acetamide;acetamide, N-(trans-4-hydroxycyclohexyl)-;

Chemical Property of TRANS-4-ACETAMIDOCYCLOHEXANOL

Chemical Property:

• Melting Point: 168.0 to 172.0 °C
• Boiling Point: 357.212 °C at 760 mmHg
• PKA: 15.01±0.40(Predicted)
• Flash Point: 169.836 °C
• PSA: 49.33000
• Density: 1.077 g/cm³
• LogP: 0.81690
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

trans-4-Acetamidocyclohexanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 23-24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TRANS-4-ACETAMIDOCYCLOHEXANOL

There total 11 articles about TRANS-4-ACETAMIDOCYCLOHEXANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

trans-4-(acetylamino)cyclohexyl acetate (90978-87-3) → N-((trans)-4-hydroxycyclohexyl)acetamide (27489-60-7)

Guidance literature:

With sodium hydroxide; at 20 ℃; for 0.5h;

DOI:10.1002/jhet.5570370229

Reference yield:

4-acetaminophenol (103-90-2,8055-08-1) → N-cyclohexylacetamide (1124-53-4) + N-((trans)-4-hydroxycyclohexyl)acetamide (27489-60-7) + cis-(N-4-hydroxycyclohexyl)acetamide (27489-61-8) + N-(4-oxocyclohexyl)acetamide (27514-08-5)

Guidance literature:

With hydrogen; RuC; In ethanol; at 119.85 ℃; under 37503 Torr; Further Variations:; Catalysts; Solvents; Product distribution;

DOI:10.1016/j.jcat.2004.11.018

Reference yield:

4-acetaminophenol (103-90-2,8055-08-1) → N-((trans)-4-hydroxycyclohexyl)acetamide (27489-60-7)

Guidance literature:

With ethanol; nickel; Hydrogenation;

DOI:10.1021/ja01102a024

upstream raw materials:

4-acetaminophenol

p-hydroxycyclohexylamine

acetic anhydride

ethanol

Downstream raw materials:

N-(trans-4-benzyloxycyclohexyl)acetamide

N-(4-oxocyclohexyl)acetamide

N-(cyclohex-3-enyl)acetamide

N-(trans-4-benzyloxycyclohexyl)-5-chlorovaleramide

Refernces

• 1、 Marinko, Petra,Obreza, Ales,Peterlin-Masic, Lucija,Krbavcic, Ales,Kikelj, Danijel. "Synthesis of 2-amino-7,8-dihydro-6(5H)-quinazolinone, 2,4-diamino-7,8- dihydro-6(5H)-quinazolinone, 5,6,7,8-tetrahydro-2,6-quinazolinediamine and 5,6,7,8-tetrahydro-2,4,6-quinazolinetriamine derivatives". . p. 405 - 409. Retrieved 2000.
• 2、 Bachiller-Baeza,Guerrero-Ruiz,Rodriguez-Ramos. "Ruthenium-supported catalysts for the stereoselective hydrogenation of paracetamol to 4-trans-acetamidocyclohexanol: Effect of support, metal precursor, and solvent". . p. 439 - 445. Retrieved 2007/10/03.