N-Ethyl-N-(2-chloroethyl)amine hydrochloride

Base Information

• Chemical Name: N-Ethyl-N-(2-chloroethyl)amine hydrochloride
• CAS No.: 4535-87-9
• Molecular Formula: C4H10ClN•ClH
• Molecular Weight: 144.044
• European Community (EC) Number: 871-462-6
• DSSTox Substance ID: DTXSID50963373
• NSC Number: 126128,106600,1120
• Mol file: 4535-87-9.mol

Synonyms:4535-87-9;(2-chloroethyl)ethylamine hydrochloride;2-chloro-n-ethylethanamine hydrochloride;(2-chloroethyl)(ethyl)amine hydrochloride;N-Ethyl-N-(2-chloroethyl)amine hydrochloride;WLN: G2M2 &GH;SCHEMBL3131325;DTXSID50963373;NSC1120;ZNPQLXDWQPMSMR-UHFFFAOYSA-N;NSC-1120;NSC106600;NSC126128;AKOS026746255;AB86731;NSC-106600;NSC-126128;2-chloro-N-ethylethanamine;hydrochloride;2-ethylaminoethyl chloride hydrochloride;2-chloro-N,N-diethyl amine hydrochloride;BS-46848;2-CHLORO-N,N-DIETHYLAMINE HYDROCHLORIDE;E78745;EN300-261943;2-Chloro-N-ethylethan-1-amine--hydrogen chloride (1/1);F2147-1523

Chemical Property of N-Ethyl-N-(2-chloroethyl)amine hydrochloride

Chemical Property:

• Vapor Pressure: 10mmHg at 25°C
• Boiling Point: 129.7°Cat760mmHg
• Flash Point: 32.3°C
• Density: g/cm³
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 143.0268547
• Heavy Atom Count: 7
• Complexity: 23.5

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCNCCCl.Cl

Technology Process of N-Ethyl-N-(2-chloroethyl)amine hydrochloride

There total 5 articles about N-Ethyl-N-(2-chloroethyl)amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-(Ethylamino)ethanol (110-73-6) → N-(2-chloroethyl)ethylamine hydrochloride (4535-87-9)

Guidance literature:

With thionyl chloride; In chloroform; for 6h; Heating;

DOI:10.1248/cpb.50.941

Reference yield:

→ N-(2-chloroethyl)ethylamine hydrochloride (4535-87-9)

Guidance literature:

With thionyl chloride; chloroform;

DOI:10.1021/ja01854a018

Reference yield:

N-ethylaziridine (1072-45-3) → N-(2-chloroethyl)ethylamine hydrochloride (4535-87-9)

Guidance literature:

With hydrogenchloride; durch Eindampfen;

DOI:10.1021/ja01854a018

upstream raw materials:

N-ethylaziridine

ethyl-chloro-(2-chloro-ethyl)-amine

2-(Ethylamino)ethanol

hydrogenchloride

Downstream raw materials:

ethyl-(2-chloro-ethyl)-carbamic acid benzyl ester

Benzilsaeure-<2-aethylamino-aethylester>

N-methyl-N'-ethylethane-1,2-diamine

Desethylamiodarone hydrochloride

Refernces

• 1、 Hirokawa, Yoshimi,Morie, Toshiya,Yamazaki, Hiroshi,Yoshida, Naoyuki,Kato, Shiro. "A novel series of N-(hexahydro-1,4-diazepin-6-yl) and N-(hexahydroazepin-3-yl)benzamides with high affinity for 5-HT3 and dopamine D2 receptors". . p. 619 - 624. Retrieved 2007/10/03.