BENZYL 2-CHLOROETHYL ETHER

Base Information

• Chemical Name: BENZYL 2-CHLOROETHYL ETHER
• CAS No.: 17229-17-3
• Molecular Formula: C9H11ClO
• Molecular Weight: 170.639
• Hs Code.: 2909309090
• Mol file: 17229-17-3.mol

Synonyms:BENZYL 2-CHLOROETHYL ETHER;BENZENE, [(2-CHLOROETHOXY)METHYL]-;1-(BENZYLOXY)-2-CHLOROETHANE;2-(BENZYLOXY)ETHYL CHLORIDE;(2-CHLOROETHOXYMETHYL)BENZENE;Benxyl 2-Chloroethyl ether;(2-Chloromethoxy)-Methyl-Benzene;Benzene, 1-[(2-chloroethoxy)methyl]-

Chemical Property of BENZYL 2-CHLOROETHYL ETHER

Chemical Property:

• Vapor Pressure: 0.0884mmHg at 25°C
• Melting Point: 27.4-27.8 °C
• Refractive Index: 1.5180-1.5220
• Boiling Point: 232.7°Cat760mmHg
• Flash Point: 100.6°C
• PSA: 9.23000
• Density: 1.09g/cm³
• LogP: 2.44200
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: Chloroform, Hexanes (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

Benzyl 2-Chloroethyl Ether ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Benzyl 2-Chloroethyl Ether is used in the synthesis of phosphane ligands with novel linker units that are complexed with rhodium to be used as building blocks for dendrimer catalysts. Also used in th e formation of 2,6-diphenylpyrazine molecule derivatives which display cytotoxic properties.

Technology Process of BENZYL 2-CHLOROETHYL ETHER

There total 19 articles about BENZYL 2-CHLOROETHYL ETHER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-Benzyloxyethanol (622-08-2,1201808-31-2) → benzyl 2-chloroethyl ether (17229-17-3)

Guidance literature:

With pyridine; thionyl chloride; at 65 ℃; for 4h; Inert atmosphere;

DOI:10.1039/b818606e

Reference yield: 90.0%

benzyl bromide (100-39-0) + 2-chloro-ethanol (107-07-3) → benzyl 2-chloroethyl ether (17229-17-3)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 25 ℃; for 6h;

DOI:10.1039/c9cc07100h

Reference yield:

N-benzyl-N,N,N-triethylammonium chloride (56-37-1) + 1,2-dichloro-ethane (107-06-2,52399-93-6) + benzyl alcohol (100-51-6,185532-71-2) → benzyl 2-chloroethyl ether (17229-17-3) + dibenzyl ether (103-50-4) + N,N-diethylbenzylamine (772-54-3) + benzaldehyde (100-52-7) + benzyl chloride (100-44-7) + triethylamine (121-44-8)

Guidance literature:

With sodium hydroxide; In water; at 75 - 80 ℃; Product distribution; catalytically active organic phase analysis;

DOI:10.1007/BF00961109

upstream raw materials:

oxirane

benzyl chloride

2-Benzyloxyethanol

2-chloro-ethanol

Downstream raw materials:

N-(ω-benzyloxyethyl)-N-dodecyl-N,N-dimethylammonium chloride

1-(2-benzyloxy-ethyl)-3,4-dihydro-1H-naphthalen-2-one

(2-chloro-ethyl)-(4-nitro-benzyl)-ether

((2-azidoethoxy)methyl)benzene

Refernces

• 1、 Yu, Sisi,An, Yuehui,Wang, Wenlin,Xu, Ze-Feng,Li, Chuan-Ying. "Synthesis of Piperidine Derivatives by Rhodium- Catalyzed Tandem Reaction of N-Sulfonyl-1,2,3-Triazole and Vinyl Ether". supporting information. p. 2125 - 2130. Retrieved 2018/04/17.
• 2、 Augustowska, Ewelina,Boiron, Antoine,Deffit, Jerome,Six, Yvan. "Kulinkovich-type reactions of thioamides: Similar to those of carboxylic amides?". supporting information; experimental part. p. 5031 - 5033. Retrieved 2012/06/01.