N-(4-Hydroxycyclohexyl)acetamide

Base Information Edit

Chemical Name:N-(4-Hydroxycyclohexyl)acetamide
CAS No.:23363-88-4
Molecular Formula:C8H15NO2
Molecular Weight:157.213
Hs Code.:2924299090
European Community (EC) Number:245-613-6,248-491-2
NSC Number:150046,130812
DSSTox Substance ID:DTXSID20946032,DTXSID701282648
Nikkaji Number:J1.247.214E,J228.940G,J250.521E
Mol file:23363-88-4.mol

Synonyms:23363-88-4;N-(4-Hydroxycyclohexyl)acetamide;27489-60-7;trans-4-Acetamidocyclohexanol;4-Acetamidocyclohexanol;N-(Trans-4-hydroxycyclohexyl)acetamide;Acetamide, N-(4-hydroxycyclohexyl)-;rel-N-((1r,4r)-4-Hydroxycyclohexyl)acetamide;Acetamide, N-(trans-4-hydroxycyclohexyl)-;EINECS 245-613-6;EINECS 248-491-2;MFCD06797038;trans-N-(4-Hydroxycyclohexyl)acetamide;ACETAMIDE,N-(TRANS-4-HYDROXYCYCLOHEXYL)-;N-(4-Hydroxycyclohexyl)acetamide, AldrichCPR;NSC150046;cis-4-acetaminocyclohexanol;SCHEMBL49325;SCHEMBL942931;SCHEMBL942932;SCHEMBL8749702;SCHEMBL18175826;DTXSID20946032;DTXSID701282648;CBA48960;YAA36388;AC9234;MFCD00051422;NSC130812;4alpha-Acetylaminocyclohexane-1beta-ol;AKOS005068325;AKOS024258158;AKOS027320972;N-(4-Hydroxycyclohexyl)acetamide, cis;4alpha-Acetylaminocyclohexane-1alpha-ol;NSC 130812;NSC 150046;NSC-130812;NSC-150046;SB83836;trans-N-acetyl-4-hydroxycyclohexylamine;N-(4-Hydroxycyclohexyl)ethanimidic acid;4-(4-MORPHOLINYL)-PICOLINICACID;N-(4-Hydroxycyclohexyl)acetamide, trans;AS-19466;BS-23870;SY019656;Acetamide, N-(4-hydroxycyclohexyl)-, cis-;A1162;CS-0099870;CS-0116732;FT-0604943;FT-0652517;Acetamide, N-(4-hydroxycyclohexyl)-, trans-;D76040;A816690;F6546-1582

Suppliers and Price of N-(4-Hydroxycyclohexyl)acetamide

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Acetamidocyclohexanol
2.5g
$ 1260.00

TCI Chemical
4-Acetamidocyclohexanol (cis- and trans- mixture) >98.0%(GC)
25g
$ 47.00

Labseeker
4-ACETAMIDOCYCLOHEXANOL 98
25g
$ 200.00

Chemenu
N-(4-hydroxycyclohexyl)acetamide 95+%
100g
$ 102.00

American Custom Chemicals Corporation
4-ACETAMIDOCYCLOHEXANOL 95.00%
25G
$ 1189.28

Ambeed
N-(4-Hydroxycyclohexyl)acetamide(cis-andtrans-mixture) 97%
25g
$ 9.00

Ambeed
N-(4-Hydroxycyclohexyl)acetamide(cis-andtrans-mixture) 97%
5g
$ 5.00

AK Scientific
4-Acetamidocyclohexanol,cis/transmixture
25g
$ 62.00

AK Scientific
4-Acetamidocyclohexanol,cis/transmixture
100g
$ 121.00

aablocks
4-Acetamidocyclohexanol 97%
500g
$ 534.00

Total 58 raw suppliers

Chemical Property of N-(4-Hydroxycyclohexyl)acetamide Edit

Chemical Property:

Vapor Pressure:1.54E-06mmHg at 25°C
Melting Point:162 °C
Refractive Index:1.491
Boiling Point:357.2 °C at 760 mmHg
PKA:15.01±0.40(Predicted)
Flash Point:169.8 °C
PSA：49.33000
Density:1.07 g/cm³
LogP:0.81690
Storage Temp.:Sealed in dry,Room Temperature
Solubility.:Dichloromethane (Slightly, Heated), DMSO (Slightly), Methanol (Slightly), Water
XLogP3:0.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:157.110278721
Heavy Atom Count:11
Complexity:139

Purity/Quality:

99% ^*data from raw suppliers

4-Acetamidocyclohexanol ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)NC1CCC(CC1)O
Uses trans-4-Acetamidocyclohexanol is an intermediate in the synthesis of 4”-trans-Hydroxy Cilostazol (H918300), a metabolite of Cilostazol (C441500), a potent phosphodiesterase III A (PDE3A) inhibitor (IC50=0.2uM) and inhibitor of adenosine uptake. Has antimitogeni, antithrombotic, vasodilatory and cardiotonic properties in vivo. Also affects lipid levels in vivo.

Technology Process of N-(4-Hydroxycyclohexyl)acetamide

There total 3 articles about N-(4-Hydroxycyclohexyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 103-90-2,8055-08-1
4-acetaminophenol

: 23363-88-4
trans-N-acetyl-4-hydroxycyclohexylamine

Guidance literature:: With chloro(1,5-cyclooctadiene)rhodium(I) dimer; borane-ammonia complex; In 2,2,2-trifluoroethanol; at 20 ℃; for 24h; Schlenk technique; Inert atmosphere; Sealed tube;
DOI:10.1002/chem.202002777