N-(TERT-BUTYL)-2-CHLOROACETAMIDE

Base Information

• Chemical Name: N-(TERT-BUTYL)-2-CHLOROACETAMIDE
• CAS No.: 15678-99-6
• Molecular Formula: C6H12ClNO
• Molecular Weight: 149.62
• Hs Code.: 2924199090
• Mol file: 15678-99-6.mol

Synonyms:Acetamide,N-tert-butyl-2-chloro- (6CI,8CI);2-Chloro-N-t-butylacetamide;N-Chloroacetyl-tert-butylamine;N-tert-Butyl-2-chloroacetamide;NSC 8361;a-Chloro-N-tert-butylacetamide;N-(tert-Butyl) 2-chloroacetamide;n-tert-butyl-2-chloroacetamide;

Chemical Property of N-(TERT-BUTYL)-2-CHLOROACETAMIDE

Chemical Property:

• Vapor Pressure: 0.0203mmHg at 25°C
• Refractive Index: 1.441
• Boiling Point: 251.6 °C at 760 mmHg
• Flash Point: 106 °C
• PSA: 29.10000
• Density: 1.032 g/cm³
• LogP: 1.53080
• Solubility.: Dichloromethane, Ethyl Acetate, Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-Chloroacetyl-tert-butylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: In conjunction to thiocarbamate herbicides prevents the onset of herbicide injury to corn.

Technology Process of N-(TERT-BUTYL)-2-CHLOROACETAMIDE

There total 7 articles about N-(TERT-BUTYL)-2-CHLOROACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.5%

tert-butylamine (75-64-9) + chloroacetyl chloride (79-04-9) → N-tert-butylchloroacetamide (15678-99-6)

Guidance literature:

In ethyl acetate; Ambient temperature;

DOI:10.1021/jm00048a015

Reference yield: 87.0%

chloroacetonitrile (107-14-2) + tert-butyl alcohol (75-65-0) → N-tert-butylchloroacetamide (15678-99-6)

Guidance literature:

With magnesium hydrogen sulfate; at 20 ℃; for 0.5h;

DOI:10.1081/SCC-100104410

Reference yield: 82.0%

→ N-tert-butylchloroacetamide (15678-99-6)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; at 20 ℃; for 0.166667h;

In dichloromethane; for 2h; Cooling with ice;

upstream raw materials:

tert-butylamine

chloroacetyl chloride

2-benzenesulfonyl-1-tert-butyl-2-chloro-aziridine

monochloro-acetyl chloride

Downstream raw materials:

N-(toluene-4-sulfonyl)-L-prolyl-4-[(N-tert-butylaminocarbonyl)methoxy]-L-phenylalanine

1,3-(bis-2,6-diisopropylphenyl)-4-(tert-butylaminide)-imidazolium

1,3-(bis-2,6-diisopropylphenyl)-4-(tert-butylamino)-imidazolium bromide

1-(benzyl)-3-(N-tert-butylacetamido)imidazolium chloride

Refernces

• 1、 Zwettler, Niklas,Dupé, Antoine,Schachner, J?rg A.,Belaj, Ferdinand,M?sch-Zanetti, Nadia C.. "Templated C-C and C-N Bond Formation Facilitated by a Molybdenum(VI) Metal Center". . p. 11969 - 11976. Retrieved 2015.
• 2、 Bulitta, Jürgen B.,Dharuman, Suresh,Lee, Richard E.,Reeve, Stephanie M.,Wallace, Miranda J.. "Synthesis and Structure–Activity Relationship of Thioacetamide-Triazoles against Escherichia coli". supporting information. . Retrieved 2022/03/01.
• 3、 Fang, Zi-Mian,Guo, Deng-Xuan,Ji, Jin,Liu, Li-Wei,Qi, Pu-Ying,Shao, Wu-Bin,Wang, Jin-Jing,Wang, Pei-Yi,Yang, Song,Zhou, Xiang. "Synthesis and Biological Evaluation of 1,2,4-Triazole Thioethers as Both Potential Virulence Factor Inhibitors against Plant Bacterial Diseases and Agricultural Antiviral Agents against Tobacco Mosaic Virus Infections". . p. 15108 - 15122. Retrieved 2021/12/27.