Fluocortolone Pivalate

Base Information

• Chemical Name: Fluocortolone Pivalate
• CAS No.: 29205-06-9
• Molecular Formula: C₂₇H₃₇FO₅
• Molecular Weight: 460.586
• European Community (EC) Number: 249-504-4
• UNII: 9J8AL6K50Q
• DSSTox Substance ID: DTXSID30951798
• Nikkaji Number: J250.794C
• Wikidata: Q27272623
• Mol file: 29205-06-9.mol

Synonyms:Caproate, Fluocortolone;Fluocortolone;Fluocortolone Caproate;Fluocortolone Pivalate;Pivalate, Fluocortolone;Ultralan

Chemical Property of Fluocortolone Pivalate

Chemical Property:

• Melting Point: 187 °C
• Boiling Point: 572.3°Cat760mmHg
• PKA: 14.05±0.70(Predicted)
• Flash Point: 299.9°C
• PSA: 80.67000
• Density: 1.19g/cm³
• LogP: 4.23370
• Solubility.: Practically insoluble in water, freely soluble in methylene chloride and in dioxan, sparingly soluble in ethanol (96 per cent).
• XLogP3: 4.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 5
• Exact Mass: 460.26250244
• Heavy Atom Count: 33
• Complexity: 929

Purity/Quality:

98%,99%, ^*data from raw suppliers

Fluocortolone pivalate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1CC2C3CC(C4=CC(=O)C=CC4(C3C(CC2(C1C(=O)COC(=O)C(C)(C)C)C)O)C)F
• Isomeric SMILES: C[C@@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@H]3[C@H](C[C@@]2([C@H]1C(=O)COC(=O)C(C)(C)C)C)O)C)F
• Uses: Fluocortolone Pivalate is a glucocorticoid.

Technology Process of Fluocortolone Pivalate

There total 3 articles about Fluocortolone Pivalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2,2-Dimethyl-propionic acid 2-((6S,10R,11R,13S,16R,17S)-6-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl ester (25091-88-7,29205-06-9)

Guidance literature:

Alkohol I (R=H), ClCH2CH2Cl, (Me3CCO)2O;

Reference yield:

→ 2,2-Dimethyl-propionic acid 2-(6-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl ester (25091-88-7,29205-06-9)

Guidance literature:

Entspr. 11β,21-Dihydroxy-Verb.;

Reference yield:

→ 6α-Fluor-11β-hydroxy-21-trimethylacetoxy-16α-methyl-1,4-pregnadien-3,20-dion (25091-88-7,29205-06-9)

Guidance literature:

entspr. 6α-Fluor-9α-brom-pregnadien, Tributylzinnhydrid;