3-HYDROXY-4-METHYL-2(3H)-THIAZOLETHIONE

Base Information

• Chemical Name: 3-HYDROXY-4-METHYL-2(3H)-THIAZOLETHIONE
• CAS No.: 49762-08-5
• Molecular Formula: C4H5NOS2
• Molecular Weight: 147.222
• Hs Code.: 2934100090
• Mol file: 49762-08-5.mol

Synonyms:3-Hydroxy-4-methyl-2(3H)-thiazolethione;3-Hydroxy-4-methyl-2,3-dihydrothiazole-2-thione;3-Hydroxy-4-methylthiazoline-2-thione;N-Hydroxy-4-methylthiazole-2(3H)-thione;NSC 373984;

Chemical Property of 3-HYDROXY-4-METHYL-2(3H)-THIAZOLETHIONE

Chemical Property:

• Appearance/Colour: Green-brown to brown solid
• Vapor Pressure: 0.000947mmHg at 25°C
• Melting Point: 92-94 °C(lit.)
• Refractive Index: 1.773
• Boiling Point: 269.7 °C at 760 mmHg
• PKA: 4.75±0.40(Predicted)
• Flash Point: 116.9 °C
• PSA: 85.49000
• Density: 1.58 g/cm³
• LogP: 1.82480
• Storage Temp.: 0-6°C
• Solubility.: methanol: soluble25mg/mL, clear, brownish-yellow to brown

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Hydroxy-4-methyl-1,3-thiazole-2-thione ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-HYDROXY-4-METHYL-2(3H)-THIAZOLETHIONE

There total 2 articles about 3-HYDROXY-4-METHYL-2(3H)-THIAZOLETHIONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

O-ethyl-S(2-oximinopropyl)dithiocarbonate (49762-81-4) → 3-hydroxy-4-methylthiazole-2(3H)-thione (49762-08-5)

Guidance literature:

With potassium hydroxide; In dichloromethane; water; at 0 ℃;

DOI:10.1016/S0040-4039(00)94229-1

Reference yield:

→ 3-hydroxy-4-methylthiazole-2(3H)-thione (49762-08-5)

Guidance literature:

Reference yield: 90.0%

3-hydroxy-4-methylthiazole-2(3H)-thione (49762-08-5) + (3R,4R,5S)-4-acetamido-5-[(tert-butoxycarbonyl)-amino]-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylic acid (764639-63-6) → C23H35N3O6S2 (1373702-86-3)

Guidance literature:

(3R,4R,5S)-4-acetamido-5-[(tert-butoxycarbonyl)-amino]-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylic acid; With dmap; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In dichloromethane; at 25 ℃; for 0.5h;

3-hydroxy-4-methylthiazole-2(3H)-thione; In dichloromethane; at 25 ℃; for 3h;

DOI:10.1016/j.ejmech.2014.04.082

upstream raw materials:

O-ethyl-S(2-oximinopropyl)dithiocarbonate

Downstream raw materials:

3-diphenylacetoxy-4-methylthiazole-2(3H)-thione

3-dibenzylacetoxy-4-methylthiazole-2(3H)-thione

3-triphenylacetoxy-4-methylthiazole-2(3H)-thione

3-(3,3-diphenylpropionoxy-)-4-methylthiazole-2(3H)-thione

Refernces

• 1、 -. "Biocidal composition and its use". . . Retrieved 2008/06/13.
• 2、 Saiic, Radomir N.,Cekovic, Zivorad. "Cyclopentane ring formation in the cycloaddition reaction of 3-alkenyl radicals to radicophilic olefins". . p. 3627 - 3640. Retrieved 2007/10/02.