1-ANILINOCYCLOHEXANECARBONITRILE

Base Information

• Chemical Name: 1-ANILINOCYCLOHEXANECARBONITRILE
• CAS No.: 64269-06-3
• Molecular Formula: C13H16 N2
• Molecular Weight: 200.283
• Hs Code.: 2926909090
• Mol file: 64269-06-3.mol

Synonyms:Cyclohexanecarbonitrile,1-anilino- (7CI); 1-Anilino-1-cyclohexanecarbonitrile;1-Phenylaminocyclohexanecarbonitrile; N-(1-Cyanocyclohexyl)aniline; NSC 155543

Chemical Property of 1-ANILINOCYCLOHEXANECARBONITRILE

Chemical Property:

• Vapor Pressure: 8.45E-06mmHg at 25°C
• Melting Point: 76 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 374.3°C at 760 mmHg
• PKA: 2.04±0.20(Predicted)
• Flash Point: 180.2°C
• PSA: 35.82000
• Density: 1.06g/cm³
• LogP: 3.39798

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-ANILINOCYCLOHEXANECARBONITRILE

There total 18 articles about 1-ANILINOCYCLOHEXANECARBONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.8%

trimethylsilyl cyanide (7677-24-9) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + aniline (62-53-3) → 1-(phenylamino)cyclohexanecarbonitrile (64269-06-3)

Guidance literature:

With 1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; phenol; In toluene; at 40 ℃; Molecular sieve; Inert atmosphere;

DOI:10.1039/b924272d

Reference yield: 95.0%

Acetyl cyanide (631-57-2) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + aniline (62-53-3) → 1-(phenylamino)cyclohexanecarbonitrile (64269-06-3)

Guidance literature:

With N,N-dimethyl-cyclohexanamine; In water; at 20 ℃; for 5h;

DOI:10.1039/b914151k

Reference yield: 92.0%

trimethylsilyl cyanide (7677-24-9) + N-cyclohexylidenebenzenamine (1132-38-3) → 1-(phenylamino)cyclohexanecarbonitrile (64269-06-3)

Guidance literature:

With Co(II) complex supported on mesoporous SBA-15; at 40 ℃; for 10h; Sealed tube;

DOI:10.1039/c1gc15741h

upstream raw materials:

potassium cyanide

aniline hydrochloride

cyclohexanone

aniline

Downstream raw materials:

spiro[cyclohexanyl-1',2-(5-imino-1-phenyl)pyrrolo(3,4-c)pyrazol(1H,2H)-5-one]

spiro[cyclohexanyl-1',2-(3-amino-1-phenyl)pyrazinolidin-6-one]

spiro[cyclohexanyl-1',2-(4-acetyl-3-amino-1-phenyl)pyrrol-5-one]

spiro[cyclohexanyl-1',3-(2-imino-7-methyl-4-phenyl)-1,4-oxazepin-5-one]

Refernces

• 1、 Abd-Allah, Walaa Hamada,Salman, Asmaa,Sabry Saad, Samah. "Anticancer activity of newly synthesized 1,1-disubstituted cyclohexane-1-carboxamides: in vitro caspases mediated apoptosis activators in human cancer cell lines and their molecular modeling". . p. 933 - 947. Retrieved 2019.
• 2、 Azam, Khan,Gui, Liu-Cheng,Liang, Guang-Ming,Ni, Qing-Ling,Wang, Xiu-Jian,Xiong, Peng,Zeng, Jian-Qiang. "A Discrete Tetrahedral Indium Cage as an Efficient Heterogeneous Catalyst for the Fixation of CO2 and the Strecker Reaction of Ketones". supporting information. p. 1653 - 1659. Retrieved 2020/02/28.
• 3、 Nasseri, Mohammad Ali,Ramezani-Moghadam, Simin,Kazemnejadi, Milad,Allahresani, Ali. "Cu/Ni-doped sulfated zirconium oxide immobilized on CdFe2O4 NPs: a cheap, sustainable and magnetically recyclable inorgano-catalyst for the efficient preparation of α-aminonitriles in aqueous media". . p. 4233 - 4256. Retrieved 2020/07/08.