Technology Process of 4aα,9β-Dihydroxy-1β-methyl-8-methylenegibbane-1α,10β-dicarboxylic acid 1,4a-lactone
There total 15 articles about 4aα,9β-Dihydroxy-1β-methyl-8-methylenegibbane-1α,10β-dicarboxylic acid 1,4a-lactone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
methanol;
for 60h;
Ambient temperature;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: diethyl ether
2: 240 mg / SeO2, tert-butyl hydroperoxide / CH2Cl2; H2O / 17 h / Ambient temperature
3: 45 percent / p-TosOH, dihydropyran / CH2Cl2 / 3 h / Ambient temperature
4: 4 mg / aq. K2CO3 (1 mol/l) / methanol / 60 h / Ambient temperature
With
3,4-dihydro-2H-pyran; tert.-butylhydroperoxide; selenium(IV) oxide; potassium carbonate; toluene-4-sulfonic acid;
In
methanol; diethyl ether; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 240 mg / SeO2, tert-butyl hydroperoxide / CH2Cl2; H2O / 17 h / Ambient temperature
2: 45 percent / p-TosOH, dihydropyran / CH2Cl2 / 3 h / Ambient temperature
3: 4 mg / aq. K2CO3 (1 mol/l) / methanol / 60 h / Ambient temperature
With
3,4-dihydro-2H-pyran; tert.-butylhydroperoxide; selenium(IV) oxide; potassium carbonate; toluene-4-sulfonic acid;
In
methanol; dichloromethane; water;