desferriferrithiocin

Base Information

• Chemical Name: desferriferrithiocin
• CAS No.: 76045-30-2
• Molecular Formula: C10H10 N2 O3 S
• Molecular Weight: 238.267
• Mol file: 76045-30-2.mol

Synonyms:4-Thiazolecarboxylicacid, 4,5-dihydro-2-(3-hydroxy-2-pyridinyl)-4-methyl-, (S)-; CGP 23841A;Deferriferrithiocin; Desferriferrithiocin

Chemical Property of desferriferrithiocin

Chemical Property:

• Vapor Pressure: 6.22E-06mmHg at 25°C
• Boiling Point: 378.6°C at 760 mmHg
• Flash Point: 182.8°C
• PSA: 108.08000
• Density: 1.48g/cm³
• LogP: 0.55950
• Storage Temp.: 2-8°C

Purity/Quality:

99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of desferriferrithiocin

There total 1 articles about desferriferrithiocin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3-hydroxypyridine-2-carbonitrile (932-35-4) + (S)-α-methylcysteine hydrochloride → (S)-4,5-dihydro-2-(3-hydroxy-2-pyridinyl)-4-methyl-4-thiazolecarboxylic acid (76045-30-2)

Guidance literature:

With triethylamine; In methanol; for 24h; Heating;

DOI:10.1016/S0040-4020(01)82385-1

Reference yield:

(S)-4,5-dihydro-2-(3-hydroxy-2-pyridinyl)-4-methyl-4-thiazolecarboxylic acid (76045-30-2) → 3-hydroxypyridine-2-carboxylic acid (874-24-8) + (S)-α-methyl cysteine (239101-34-9)

Guidance literature:

With hydrogenchloride; at 100 ℃; for 1.33333h; Title compound not separated from byproducts;

DOI:10.1021/jm990058s

Reference yield:

2,4-dihydroxybenzonitrile (64419-24-5) + (S)-4,5-dihydro-2-(3-hydroxy-2-pyridinyl)-4-methyl-4-thiazolecarboxylic acid (76045-30-2) → deferitrin (239101-33-8)

Guidance literature:

With hydrogenchloride; phosphate buffer; sodium hydrogencarbonate; Yield given; Multistep reaction; 1.) 100 deg C, 80 min, 2.) CH₃OH, 71 deg C, 3.5 d;

DOI:10.1021/jm990058s

upstream raw materials:

3-hydroxypyridine-2-carbonitrile

Downstream raw materials:

deferitrin

3-hydroxypyridine-2-carboxylic acid

(S)-α-methyl cysteine

desferrithiocin

Refernces