[1-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperidin-4-yl](azocan-1-yl)methanone hydrochloride (1:1)

Base Information

• Chemical Name: [1-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperidin-4-yl](azocan-1-yl)methanone hydrochloride (1:1)
• CAS No.: 80024-83-5
• Molecular Formula: C₂₃H₃₃N₅O₃*ClH
• Molecular Weight: 464.008
• Mol file: 80024-83-5.mol

Synonyms:

Chemical Property of [1-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperidin-4-yl](azocan-1-yl)methanone hydrochloride (1:1)

Chemical Property:

• Vapor Pressure: 9.91E-18mmHg at 25°C
• Boiling Point: 668.4°Cat760mmHg
• Flash Point: 358°C
• Density: g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [1-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperidin-4-yl](azocan-1-yl)methanone hydrochloride (1:1)

There total 4 articles about [1-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperidin-4-yl](azocan-1-yl)methanone hydrochloride (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-(Azocane-1-carbonyl)-N-(2-cyano-4,5-dimethoxy-phenyl)-piperidine-1-carboximidothioic acid methyl ester (80030-69-9) → [1-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperidin-4-yl]-azocan-1-yl-methanone; hydrochloride (80024-83-5)

Guidance literature:

With ammonium chloride; In formamide; at 120 ℃;

DOI:10.1021/jm00364a014

Reference yield:

4-(Azocane-1-carbonyl)-piperidine-1-carboxylic acid benzyl ester → [1-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperidin-4-yl]-azocan-1-yl-methanone; hydrochloride (80024-83-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 97 percent / 1 N aq. HCl, H₂ / Pd/C / methanol / 760 Torr / Ambient temperature

2: 67 percent / dimethylformamide / 0 °C

3: 97 percent / calcium oxide / CHCl₃ / Heating

4: 80 percent / ammonium chloride / formamide / 120 °C

With hydrogenchloride; ammonium chloride; hydrogen; calcium oxide; palladium on activated charcoal; In methanol; chloroform; formamide; N,N-dimethyl-formamide;

DOI:10.1021/jm00364a014

Reference yield:

Azocan-1-yl-piperidin-4-yl-methanone (86542-90-7) → [1-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperidin-4-yl]-azocan-1-yl-methanone; hydrochloride (80024-83-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 67 percent / dimethylformamide / 0 °C

2: 97 percent / calcium oxide / CHCl₃ / Heating

3: 80 percent / ammonium chloride / formamide / 120 °C

With ammonium chloride; calcium oxide; In chloroform; formamide; N,N-dimethyl-formamide;

DOI:10.1021/jm00364a014

upstream raw materials:

4-(Azocane-1-carbonyl)-N-(2-cyano-4,5-dimethoxy-phenyl)-piperidine-1-carboximidothioic acid methyl ester

Azocan-1-yl-piperidin-4-yl-methanone

4-(Azocane-1-carbonyl)-piperidine-1-carbothioic acid (2-cyano-4,5-dimethoxy-phenyl)-amide

Refernces