r-Safranic acid

Base Information

• Chemical Name: r-Safranic acid
• CAS No.: 70416-88-5
• Molecular Formula: C₁₀H₁₄O₂
• Molecular Weight: 166.22
• Mol file: 70416-88-5.mol

Synonyms:

Chemical Property of r-Safranic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of r-Safranic acid

There total 3 articles about r-Safranic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Ethyl 2,6,6-trimethyl-4-hydroxy-2-cyclohexene-1-carboxylate (51769-11-0) → 2,6,6-trimethyl-cyclohexa-2,4-dienecarboxylic acid (70416-88-5,78420-67-4)

Guidance literature:

With phosphorus pentoxide; toluene;

DOI:10.1002/hlca.19480310129 DOI:10.1002/hlca.19500330643

Reference yield:

ethyl 2,6,6-trimethyl-4-oxocyclohex-2-ene-1-carboxylate (23068-96-4) → 2,6,6-trimethyl-cyclohexa-2,4-dienecarboxylic acid (70416-88-5,78420-67-4)

Guidance literature:

With aluminum isopropoxide; isopropyl alcohol; Behandeln des Reaktionsprodukts mit wss. Salzsaeure;

DOI:10.1002/hlca.19480310129 DOI:10.1002/hlca.19500330643

Reference yield:

ethyl 2-acetyl-3-methylbut-2-enoate (35044-52-1) → 2,6,6-trimethyl-cyclohexa-2,4-dienecarboxylic acid (70416-88-5,78420-67-4)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium tert-butylate; tert-butyl alcohol

2: aluminium isopropylate; isopropyl alcohol / unter Entfernen des entstehenden Acetons

3: phosphorus (III)-bromide; pyridine; petroleum ether / -10 - 90 °C / Erhitzen des Reaktionsprodukts mit Kaliumhydroxid in Butanol-⁽¹⁾

With pyridine; potassium tert-butylate; phosphorus tribromide; aluminum isopropoxide; isopropyl alcohol; Petroleum ether; tert-butyl alcohol;

DOI:10.1002/hlca.19480310129

upstream raw materials:

ethyl 2,6,6-trimethyl-4-oxocyclohex-2-ene-1-carboxylate

Ethyl 2,6,6-trimethyl-4-hydroxy-2-cyclohexene-1-carboxylate

ethyl 2-acetyl-3-methylbut-2-enoate