Clorgyline hydrochloride

Base Information

• Chemical Name: Clorgyline hydrochloride
• CAS No.: 17780-75-5
• Molecular Formula: C13H15 Cl2 N O . Cl H
• Molecular Weight: 308.635
• Hs Code.: 2922299090
• European Community (EC) Number: 241-760-5
• NSC Number: 759306
• UNII: H38V165133
• DSSTox Substance ID: DTXSID3045778
• Wikidata: Q27279591
• ChEMBL ID: CHEMBL539507
• Mol file: 17780-75-5.mol

Synonyms:CLORGYLINE HYDROCHLORIDE;17780-75-5;CLORGILINE HYDROCHLORIDE;Clorgyline HCl;N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride;EINECS 241-760-5;MLS000028750;DTXSID3045778;UNII-H38V165133;N-(3-(2,4-dichlorophenoxy)propyl)-N-methylprop-2-yn-1-amine hydrochloride;NSC-759306;NCGC00094088-01;SMR000058474;H38V165133;2-Propyn-1-amine, N-(3-(2,4-dichlorophenoxy)propyl)-N-methyl-, hydrochloride;3-(2,4-dichlorophenoxy)-N-methyl-N-prop-2-ynylpropan-1-amine;hydrochloride;N-(3-(2,4-Dichlorophenoxy)propyl)-N-methyl-2-propynylamine hydrochloride;DTXCID1025778;Propylamine, 3-(2,4-dichlorophenoxy)-N-methyl-N-propargyl-, hydrochloride;2-Propyn-1-amine, N-[3-(2,4-dichlorophenoxy)propyl]-N-methyl-, hydrochloride (1:1);Prestwick_762;SR-01000075629;C13H15Cl2NO.ClH;CAS-17780-75-5;N-[3-(2,4-dichlorophenoxy)propyl]-N-methyl-2-propynylamine hydrochloride;2-Propyn-1-amine, N-[3-(2,4-dichlorophenoxy)propyl]-N-methyl-, hydrochloride;2-Propynylamine, N-(3-(2,4-dichlorophenoxy)propyl)-N-methyl-, hydrochloride;2-Propynylamine, N-[3-(2,4-dichlorophenoxy)propyl]-N-methyl-, hydrochloride;2-PROPYN-1-AMINE, N-(3-(2,4-DICHLOROPHENOXY)PROPYL)-N-METHYL-, HYDROCHLORIDE (1:1);MFCD00052012;Opera_ID_713;Clorgiline (hydrochloride);CLORGILINEHYDROCHLORIDE;MLS001076555;MLS002222259;SCHEMBL467295;CHEMBL539507;HMS1569E09;HMS3750K21;Pharmakon1600-01506065;C13-H15-Cl2-N-O.Cl-H;Tox21_111243;Tox21_500746;HY-14197A;N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)-propylamine hydrochloride;NSC759306;AKOS027257188;Tox21_111243_1;CCG-213696;CS-4553;LP00746;NSC 759306;NCGC00015669-07;NCGC00094088-02;NCGC00180962-01;NCGC00261431-01;BS-15607;17780-75-5 (HCl);LS-125601;EU-0100746;SW196902-3;M 3778;N13180;J-011321;SR-01000075629-1;SR-01000075629-5;SR-01000075629-6;Q27279591;N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine HCl;2-Propynylamine, N-(3-(2,4-dichlorophenoxy)propyl)-N-methyl-, hydrochloride (7CI,8CI);N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride, >=97% (GC)

Chemical Property of Clorgyline hydrochloride

Chemical Property:

• Vapor Pressure: 2.1E-05mmHg at 25°C
• Boiling Point: 361.3°Cat760mmHg
• Flash Point: 172.3°C
• PSA: 12.47000
• Density: g/cm³
• LogP: 4.12930
• Storage Temp.: 2-8°C
• Solubility.: ≥17.65 mg/mL in DMSO; ≥18.2 mg/mL in EtOH; ≥24.8 mg/mL in H2O
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 6
• Exact Mass: 307.029747
• Heavy Atom Count: 18
• Complexity: 263

Purity/Quality:

99% ^*data from raw suppliers

N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride ≥97% (GC) ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CN(CCCOC1=C(C=C(C=C1)Cl)Cl)CC#C.Cl
• Description: Clorgyline is a potent monoamine oxidase (MAO) inhibitor that preferentially targets MAO-A over MAO-B (Kis = 0.054 and 58 μM, respectively). This inhibition is irreversible. Clorgyline is without effect on serotonin receptors, but it does inhibit the sigma receptor σ1 on Jurkat human T lymphocyte cells (IC50 = 31 nM). As MAO-A preferentially oxidizes serotonin, selective MAO-A inhibitors have applications in ameliorating depression and anxiety.
• Uses: Antidepressant;Monoamine oxidase A inhibitor N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride has been used as a monoamine oxidase A (MAO-A) inhibitor:in MAO-A biochemical assayto study its effects on the transit of serotonin (5-HT) in the human placenta explantsto study its effects on human prostate cancer cells