6-Benzylamino-2-(2-hydroxyethylamino)-7-methylpurine

Base Information

• Chemical Name: 6-Benzylamino-2-(2-hydroxyethylamino)-7-methylpurine
• CAS No.: 101622-50-8
• Molecular Formula: C₁₅H₁₈N₆O
• Molecular Weight: 298.348
• Hs Code.: 2933990090
• Mol file: 101622-50-8.mol

Synonyms:2-(2-Hydroxyethylamino)-6-benzylamino-7-methylpurine;6-Benzylamino-2-(2-hydroxyethylamino)-7-methylpurine;Isoolomoucine;

Chemical Property of 6-Benzylamino-2-(2-hydroxyethylamino)-7-methylpurine

Chemical Property:

• Appearance/Colour: Off-white solid
• Vapor Pressure: 2.83E-14mmHg at 25°C
• Refractive Index: 1.69
• Boiling Point: 579.6 °C at 760 mmHg
• Flash Point: 304.3 °C
• PSA: 87.89000
• Density: 1.36 g/cm³
• LogP: 1.52560
• Solubility.: ≤0.3mg/ml in ethanol;15mg/ml in DMSO;15mg/ml in dimethyl formamide

Purity/Quality:

99% ^*data from raw suppliers

Iso-olomoucine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Iso-olomoucine is a potent and selective inhibitor of cdc2, cdk and orther cyclin related kinases.

Technology Process of 6-Benzylamino-2-(2-hydroxyethylamino)-7-methylpurine

There total 3 articles about 6-Benzylamino-2-(2-hydroxyethylamino)-7-methylpurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-dichloro-7-methylpurine (2273-93-0) → iso-Olomoucine (101622-50-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 150 mg / butan-1-ol / 5 h / 100 °C

2: 31 mg / 3 h / 155 °C / in an evacuated sealed tube

In butan-1-ol;

DOI:10.1016/S0031-9422(00)85471-0

Reference yield:

benzylamine (100-46-9) → iso-Olomoucine (101622-50-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 150 mg / butan-1-ol / 5 h / 100 °C

2: 31 mg / 3 h / 155 °C / in an evacuated sealed tube

In butan-1-ol;

DOI:10.1016/S0031-9422(00)85471-0

Reference yield:

ethanolamine (141-43-5) + N-benzyl-2-chloro-7-methyl-7H-purin-6-amine → iso-Olomoucine (101622-50-8)

Guidance literature:

at 155 ℃; for 3h; in an evacuated sealed tube;

DOI:10.1016/S0031-9422(00)85471-0

upstream raw materials:

ethanolamine

2,6-dichloro-7-methylpurine

benzylamine

Refernces