DIPHENYLMETHANE-4-CARBOXYLIC ACID

Base Information

• Chemical Name: DIPHENYLMETHANE-4-CARBOXYLIC ACID
• CAS No.: 620-86-0
• Molecular Formula: C14H12O2
• Molecular Weight: 212.248
• Hs Code.: 2916399090
• Mol file: 620-86-0.mol

Synonyms:p-Toluicacid, a-phenyl- (6CI,7CI,8CI);4-(Phenylmethyl)benzoic acid;4-Benzylbenzoic acid;Diphenylmethane-4-carboxylic acid;NSC 172304;p-Benzylbenzoic acid;a-Phenyl-p-toluic acid;

Chemical Property of DIPHENYLMETHANE-4-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 3.32E-06mmHg at 25°C
• Melting Point: 162-164 °C
• Refractive Index: 1.605
• Boiling Point: 372.4 °C at 760 mmHg
• PKA: 4.30±0.10(Predicted)
• Flash Point: 172.1 °C
• PSA: 37.30000
• Density: 1.17 g/cm³
• LogP: 2.97560

Purity/Quality:

99%, ^*data from raw suppliers

4-BenzylbenzoicAcid ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DIPHENYLMETHANE-4-CARBOXYLIC ACID

There total 38 articles about DIPHENYLMETHANE-4-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

carbon dioxide (124-38-9,18923-20-1) + 4-fluorodiphenylmethane (587-79-1) → 4-Benzylbenzoic acid (620-86-0)

Guidance literature:

4-fluorodiphenylmethane; With C₇₈H₇₀Al₂Cl₄N₆P₄Rh₂; magnesium; ethylene dibromide; In tetrahydrofuran; at -30 ℃; for 22h; Inert atmosphere; Glovebox;

carbon dioxide; In tetrahydrofuran; at 20 ℃; for 0.5h; under 760.051 Torr;

DOI:10.1021/jacs.0c04905

Reference yield: 84.0%

1-methyl-4-(phenylmethyl)benzene (620-83-7) → 4-Benzylbenzoic acid (620-86-0)

Guidance literature:

at 140 ℃; under 21002.1 Torr;

Reference yield: 84.0%

4-benzylbenzonitrile (23450-31-9) → 4-Benzylbenzoic acid (620-86-0)

Guidance literature:

With sulfuric acid; acetic acid; for 3h; Heating;

upstream raw materials:

oxalyl dichloride

Diphenylmethane

4-carboxybenzophenone

4-benzylbenzonitrile

Downstream raw materials:

methyl 4-benzylbenzoate

p-Benzylphenyl-p-benzylbenzoat

Bis-p-benzyl-benzoylperoxid

p-Thiolcarbophenoxydiphenylmethan

Refernces

• 1、 -. "Synchronous reactor based on reaction and separation using air oxidation of substituted toluene method for producing substituted phenyl formic acid (by machine translation)". Paragraph 0053; 0054. . Retrieved 2016/12/01.
• 2、 Faridoon,Hussein, Waleed M.,Vella, Peter,Islam, Nazar Ul,Ollis, David L.,Schenk, Gerhard,McGeary, Ross P.. "3-Mercapto-1,2,4-triazoles and N-acylated thiosemicarbazides as metallo-β-lactamase inhibitors". supporting information; experimental part. p. 380 - 386. Retrieved 2012/02/04.