Osmium tetroxide

Base Information

• Chemical Name: Osmium tetroxide
• CAS No.: 20816-12-0
• Deprecated CAS: 12060-19-4,7446-13-1,7446-13-1
• Molecular Formula: OsO4
• Molecular Weight: 254.198
• Hs Code.: 28439090
• European Community (EC) Number: 244-058-7
• ICSC Number: 0528
• UN Number: 2471
• UNII: P40W033BGM
• DSSTox Substance ID: DTXSID5042245
• Wikipedia: Osmium tetroxide,Osmium_tetroxide
• Wikidata: Q422021
• NCI Thesaurus Code: C163683
• Mol file: 20816-12-0.mol

Synonyms:Acid, Osmic;Osmic Acid;Osmium Tetroxide;Tetroxide, Osmium

Chemical Property of Osmium tetroxide

Chemical Property:

• Appearance/Colour: colorless or yellow solid
• Vapor Pressure: 7 mmHg at 20 °C
• Melting Point: 40 °C
• Boiling Point: 130 °C
• Flash Point: -40 °C
• PSA: 68.28000
• Density: 1.04 g/cm³
• LogP: -0.47520
• Storage Temp.: Refrigerator
• Sensitive.: Air Sensitive
• Solubility.: Soluble in alcohol, ether, chloroform, benzene, ammonium hydroxi
• Water Solubility.: Soluble in chloroform, alcohol and ethers.Soluble in water, organic solvents, benzene, alcohol, ether, ammonium hydroxide, phosp
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 255.94114
• Heavy Atom Count: 5
• Complexity: 138
• Transport DOT Label: Poison

Purity/Quality:

Osmium tetroxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): O, T, C, T+, Xi, Xn, F
• Hazard Codes: O,T,C,T+,F,Xi,Xn
• Statements: 8-23/24/25-40-34-26/27/28-42/43-11-67-66-36/37/38-19-36/38-36/37
• Safety Statements: 17-26-27-36/37/39-45-7/9-36/37-16-28-23

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Metals -> Metals, Inorganic Compounds
• Canonical SMILES: O=[Os](=O)(=O)=O
• Inhalation Risk: A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20 °C.
• Effects of Short Term Exposure: Lachrymation. The substance is corrosive to the eyes, skin and respiratory tract. Inhalation may cause lung oedema. Exposure to high concentrations could cause death. The effects may be delayed. Medical observation is indicated.
• Effects of Long Term Exposure: Repeated or prolonged contact with skin may cause dermatitis. The substance may have effects on the kidneys.
• Physical properties: Pale, yellow crystalline solid; chlorine-like acrid odor; monoclinic crystals having terahedral structure; density 5.1 g/cm3; melts at 40.6°C; vaporizes at 129.7°C; sublimation begins below its boiling point; vapor pressure 11 torr at 27°C; critical temperature 405°C; critical pressure 170 atm; moderately soluble in water, 7.24 g/100mL at 25°C; soluble in most organic solvents.
• Uses: Osmium tetroxide is used in histopathological laboratories to stain the adipose tissue and as a stabilizing agent in scanning electron microscopy. In the chemical industry, it is used as a catalyst in the organic synthesis, particularly as the oxidizing agent in olefin-to-glycol conversion (546, 567). In the past, osmium tetroxide in the form of aqueous solution was used in forensic medicine to examine fingerprints. Osmium tetroxide is also used in medicine to treat rheumatoid arthritis. Osmium (VIII) tetraoxide (Os8+ + 4O2-→ OsO4) is a yellow crystal and probably the most important compound used as an oxidizing agent, as a biological stain in microscopy, and to detect fingerprints. Oxidizing agent, particularly for converting olefins to glycols. Catalyzes chlorate, peroxide, periodate, and other oxidations: P. N. Rylander, Organic Syntheses with Noble Metal Catalysts (Academic Press, New York, 1973) pp 121-144. As fixing and staining agent for cell and tissue studies.

Technology Process of Osmium tetroxide

There total 145 articles about Osmium tetroxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

osmium → osmium(VIII) oxide (20816-12-0) + OsOCl4 (36509-15-6,14998-32-4)

Guidance literature:

With Cl₂; O₂; In neat (no solvent); at 400°C;;

DOI:10.1016/0022-1902(57)80104-3

Reference yield:

potassium dioxalatodioxygenosmate → osmium(VIII) oxide (20816-12-0) + osmium(IV)oxide hydrate + potassium hydrogenoxalate (127-95-7,127-96-8,583-52-8,10043-22-8,20700-38-3)

Guidance literature:

With water; In water; partially decompn. of the aq. soln. of K2{OsO2(C2O4)2}*2H2O; slowly decompn. in coldness, rapidly decompn. at 80°C; equilibrium reaction;;

Reference yield:

C9H8O2OsO2 → osmium(VIII) oxide (20816-12-0) + cis-indane-1,2-diol (4370-02-9,4647-42-1,4647-43-2,67528-22-7,67528-23-8,71214-80-7,71214-82-9,78737-68-5)

Guidance literature:

With sodium chlorate; In water; heating;;

upstream raw materials:

OsS₄

osmium(VIII) fluoride

oxygen

water

Downstream raw materials:

[Os(O)(OCH₂C(C₆H₅)2O)O]2

chlorine

trioxo(N-tert-butylimido)osmium(VIII)

bis(tert-butylimino)dioxoosmium

Refernces

• 1、 Watson, Lyn R.,Thiem, Terry,Dressler, Rainer A.,Salter, Richard A.,Murad, Edmond. "Thermochemical Properties of the Osmium Oxides". . p. 8944 - 8947. Retrieved 1991.
• 2、 Thakur, Gohil S.,Doert, Thomas,Mohitkar, Shrikant,Schnelle, Walter,Felser, Claudia,Jansen, Martin. "Crystal Growth of a New 8H Perovskite Sr8Os6.3O24Exhibiting High TCFerromagnetism". . p. 2459 - 2464. Retrieved 2021.
• 3、 Xu, Xiao-Lin,Hulliger, F.. "". . p. 120 - 126. Retrieved 1989.
• 4、 Burns, Robert C.,O'Donnell, Thomas A.. "Preparation and characterization of osmium pentachloride, a new binary chloride of osmium". . p. 3081 - 3086. Retrieved 1979.
• 5、 Grimley, R. T.,Burns, R. P.,Inghram, M. G.. "". . p. 308 - 309. Retrieved 1960.