Methyl 3-formylbenzoate

Base Information

• Chemical Name: Methyl 3-formylbenzoate
• CAS No.: 52178-50-4
• Molecular Formula: C9H8O3
• Molecular Weight: 164.161
• Hs Code.: 29189900
• Mol file: 52178-50-4.mol

Synonyms:Isophthalaldehydicacid, methyl ester (6CI,7CI);3-(Methoxycarbonyl)benzaldehyde;3-Carbomethoxybenzaldehyde;3-Formylbenzoic acid methyl ester;m-(Methoxycarbonyl)benzaldehyde;

Chemical Property of Methyl 3-formylbenzoate

Chemical Property:

• Appearance/Colour: white crystalline powder
• Vapor Pressure: 0.00596mmHg at 25°C
• Melting Point: 48-52 °C
• Refractive Index: 1.557
• Boiling Point: 272.8 °C at 760 mmHg
• Flash Point: 118.2 °C
• PSA: 43.37000
• Density: 1.181 g/cm³
• LogP: 1.28570
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

Methyl 3-formylbenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 36/37/39-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Methyl 3-Formylbenzoate is a reagent being considered for detection of amyloid deposits in patients with various forms of amyloidosis. Methyl 3-formylbenzoate may be used in the preparation of the following bioactive compounds:meso-Tetrakis(3-carboxyphenyl)porphyrin via condensation with pyrrole.Methyl 3-[4-(1-methyl-3-phenylureido)phenylaminomethyl]benzoate, which shows moderate SENP1 protease inhibition activity.An N-methyl-sulfonylhydrazone derivative for use as anti-diabetic agent with good plasma stability.

Technology Process of Methyl 3-formylbenzoate

There total 24 articles about Methyl 3-formylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

carbon monoxide (201230-82-2) + methyl 3-iodo-benzoate (618-91-7) → Methyl 3-formylbenzoate (52178-50-4)

Guidance literature:

With sodium formate; In N,N-dimethyl-formamide; at 110 ℃; for 5h; under 760.051 Torr;

DOI:10.3184/174751914X13934116089943

Reference yield: 87.0%

methanol (67-56-1) + m-formylphenyl benzoic acid (619-21-6) → Methyl 3-formylbenzoate (52178-50-4)

Guidance literature:

With N,N'-dimethylaminopyridine; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1021/ja025698q

Reference yield: 86.0%

methyl 3-(dibromomethyl)benzoate → Methyl 3-formylbenzoate (52178-50-4)

Guidance literature:

With dimethyl amine; at 60 ℃; for 0.25h;

DOI:10.1055/s-2003-44390

upstream raw materials:

methanol

m-formylphenyl benzoic acid

methyl 3-cyanobenzoate

7-(methoxycarbonyl)cycloheptatriene

Downstream raw materials:

3-[(Z)-Benzylimino-methyl]-benzoic acid methyl ester

3-(2-nitro-propenyl)-benzoic acid methyl ester

5-Cyano-6-(3-methoxycarbonylphenyl)-4-methyl-2-oxo-3,6-dihydro-2H-pyrimidine-1-carboxylic acid ethyl ester

3-[(S)-((2S,5R)-4-allyl-2,5-dimethylpiperazin-1-yl)benzotriazol-1-yl-methyl]benzoic acid methyl ester

Refernces

• 1、 -. "NOVEL HETEROARYL-TRIAZOLE COMPOUNDS AS PESTICIDES". Page/Page column 113. . Retrieved 2021/06/04.
• 2、 Gao, Yongzhi,Van Haren, Matthijs J.,Moret, Ed E.,Rood, Johannes J. M.,Sartini, Davide,Salvucci, Alessia,Emanuelli, Monica,Craveur, Pierrick,Babault, Nicolas,Jin, Jian,Martin, Nathaniel I.. "Bisubstrate inhibitors of nicotinamide N-methyltransferase (NNMT) with enhanced activity". . p. 6597 - 6614. Retrieved 2019/08/20.