2,2-Dimethylaziridine

Base Information

• Chemical Name: 2,2-Dimethylaziridine
• CAS No.: 2658-24-4
• Molecular Formula: C4H9 N
• Molecular Weight: 71.1222
• Hs Code.: 2933990090
• European Community (EC) Number: 220-191-6
• NSC Number: 18620
• UNII: TCA336D1SX
• DSSTox Substance ID: DTXSID30903792
• Nikkaji Number: J62.390C
• Wikidata: Q27289895
• Mol file: 2658-24-4.mol

Synonyms:2,2-Dimethylaziridine;2658-24-4;2,2-DIMETHYLETHYLENIMINE;Aziridine, 2,2-dimethyl-;UNII-TCA336D1SX;TCA336D1SX;EINECS 220-191-6;NSC 18620;NSC-18620;AI3-50669;2,2-dimethyl-aziridine;NSC18620;Aziridine,2-dimethyl-;2,2-Dimethyl aziridine;DTXSID30903792;DIMETHYLETHYLENIMINE, 2,2-;AKOS006272907;SS-4396;FT-0653075;EN300-105514;A818520;Q27289895

Chemical Property of 2,2-Dimethylaziridine

Chemical Property:

• Vapor Pressure: 295mmHg at 25°C
• Boiling Point: 49°Cat760mmHg
• PKA: 8.28±0.40(Predicted)
• Flash Point: °C
• PSA: 21.94000
• Density: 0.78g/cm³
• LogP: 0.69700
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 71.073499291
• Heavy Atom Count: 5
• Complexity: 47.6

Purity/Quality:

99% ^*data from raw suppliers

2,2-dimethylaziridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(CN1)C

Technology Process of 2,2-Dimethylaziridine

There total 7 articles about 2,2-Dimethylaziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

→ 2,2-dimethylaziridine (2658-24-4) + 1-(2-nitro-1-imidazolyl)-3-(2,2-dimethyl-1-aziridino)-2-propanol

Guidance literature:

Reference yield: 56.0%

2-amino-2-methylpropyl hydrogensulfate (927-82-2) → 2,2-dimethylaziridine (2658-24-4)

Guidance literature:

With sodium hydroxide; In water; at 20 ℃; for 2h;

DOI:10.1055/s-0030-1257913

Reference yield:

2-Amino-2-methyl-1-propanol (124-68-5) → 2,2-dimethylaziridine (2658-24-4)

Guidance literature:

With sulfuric acid; at 170 ℃; Unter vermindertem Druck; Erwaermen des Reaktionsprodukts mit wss. Natronlauge_.;

DOI:10.1021/ja01848a504

upstream raw materials:

2-Amino-2-methyl-1-propanol

2-amino-2-methylpropyl hydrogensulfate

4,4-dimethyl-azetidin-2-one

2,2-Dimethyl-aziridine-1-carboxylic acid (4-chloro-phenyl)-amide

Downstream raw materials:

2-methyl-1-(morpholin-4-yl)propan-2-amine

N²-[2-(2,5-dimethyl-phenoxy)-1,1-dimethyl-ethyl]-1,1-dimethyl-ethanediyldiamine

N-(2-methyl-2-propenyl)acetamide

2-methylallylamin

Refernces

• 1、 Mandrugin,Rodyunin,Fedoseev,Dontsova,Rakhmanina,Konstantinova. "Synthesis of S-(2-amino-2-methylpropyl)isothioureas and their radioprotectant activity". . p. 505 - 507. Retrieved 1990.
• 2、 Chen, Xingpeng,Lin, Chao,Du, Hongguang,Xu, Jiaxi. "Efficient Direct Synthesis of Aziridine-Containing Chiral Tridentate Ligands by the Iminium-Mediated Self-Ring Opening Reaction of Enantiopure Aziridines and Salicylaldehydes". . p. 1647 - 1661. Retrieved 2019/02/27.
• 3、 Li, Xinyao,Chen, Ning,Xu, Jiaxi. "An improved and mild wenker synthesis of aziridines". experimental part. p. 3423 - 3428. Retrieved 2010/11/21.