Tert-butyl (piperidin-4-ylmethyl)carbamate

Base Information

• Chemical Name: Tert-butyl (piperidin-4-ylmethyl)carbamate
• CAS No.: 135632-53-0
• Molecular Formula: C11H22N2O2
• Molecular Weight: 214.308
• Hs Code.: 29333990
• European Community (EC) Number: 619-591-7
• DSSTox Substance ID: DTXSID00352339
• Nikkaji Number: J1.806.359J
• Wikidata: Q72448247
• Mol file: 135632-53-0.mol

Synonyms:135632-53-0;tert-butyl (piperidin-4-ylmethyl)carbamate;4-(Boc-Aminomethyl)piperidine;4-(tert-Butoxycarbonylaminomethyl)piperidine;4-Boc-aminomethyl-piperidine;tert-butyl N-(piperidin-4-ylmethyl)carbamate;4-N-Boc-aminomethyl piperidine;tert-butyl piperidin-4-ylmethylcarbamate;4-(Boc-aminomethyl) piperidine;4-(n-boc-aminomethyl)piperidine;4-n-boc-aminomethylpiperidine;tert-butyl n-(4-piperidinylmethyl)carbamate;Carbamic acid, (4-piperidinylmethyl)-, 1,1-dimethylethyl ester;piperidin-4-ylmethyl-carbamic acid tert-butyl ester;MFCD01631214;tert-butyl(piperidin-4-ylmethyl)carbamate;tert-butyl N-[(piperidin-4-yl)methyl]carbamate;(Boc-4-Aminomethyl)Piperidine;4-boc-aminomethylpiperidine;Tert-butyl N-(4-piperidylmethyl)carbamate;4-tert-Butoxycarbonylaminomethylpiperidine;PIP(4-BOC-AM);Oprea1_863302;SCHEMBL135184;4-(boc-aminomethyl)-piperidine;DTXSID00352339;AC-134;STL183351;t-butyl piperidin-4-ylmethylcarbamate;AKOS000169272;tert-butyl 4-piperidinylmethylcarbamate;CS-W009217;DU19892;PS-3360;tert-Butyl (4-Piperidylmethyl)carbamate;BP-11259;SY017681;tert-butyl piperidin-4-ylmethyl-carbamate;4-tert-butyloxycarbonylaminomethylpiperidine;Tert-butyl piperidine-4-ylmethyl-carbamate;tert-butyl-(piperidin-4-ylmethyl)carbamate;4-tert butyloxycarbonylaminomethyl piperidine;AM20080262;B4444;BB 0220189;FT-0601663;4-(t-butyloxycarbonyl-aminomethyl)-piperidine;EN300-57066;tert-Butyl [(piperidin-4-yl)methyl]carbamate;B56683;1,1-dimethylethyl (4-piperidinylmethyl)carbamate;1,1-dimethylethyl (4piperidinylmethyl)-carbamate;4-(N-tert-butyloxycarbonylaminomethyl) piperidine;4-(N-tert-butyloxycarbonylaminomethyl)piperidine;4-(tert.-Butyloxycarbonyl)aminomethyl-piperidine;piperidin-4-ylmethyl-carbamic acid t-butyl ester;(4-Piperidylmethyl)carbamic Acid tert-Butyl Ester;[piperidin-4-ylmethyl]-carbamic acid t-butyl ester;1,1-dimethylethyl (4-piperidinyl-methyl)-carbamate;4-(tert-Butoxycarbonylaminomethyl)piperidine, AldrichCPR;F8880-5628;Z285919720

Chemical Property of Tert-butyl (piperidin-4-ylmethyl)carbamate

Chemical Property:

• Appearance/Colour: white solid.
• Vapor Pressure: 0.00029mmHg at 25°C
• Melting Point: 106 °C
• Boiling Point: 321.8 °C at 760 mmHg
• PKA: 12.72±0.46(Predicted)
• Flash Point: 148.4 °C
• PSA: 50.36000
• Density: 0.981 g/cm³
• LogP: 2.23040
• Storage Temp.: Refrigerated.
• Solubility.: Soluble in DMSO.
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 214.168127949
• Heavy Atom Count: 15
• Complexity: 205

Purity/Quality:

99.9% ^*data from raw suppliers

tert-Butyl(Piperidin-4-ylmethyl)carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C,Xi
• Hazard Codes: C,Xi
• Statements: 34-36/38
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NCC1CCNCC1
• Uses: 4-(Boc-aminomethyl)piperidine is used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.

Technology Process of Tert-butyl (piperidin-4-ylmethyl)carbamate

There total 9 articles about Tert-butyl (piperidin-4-ylmethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ tert-butyl N-(4-piperidinylmethyl)carbamate (135632-53-0)

Guidance literature:

Reference yield: 81.0%

benzyl 4-(((tert-butoxycarbonyl)amino)methyl)piperidine-1-carboxylate (172348-56-0) → tert-butyl N-(4-piperidinylmethyl)carbamate (135632-53-0)

Guidance literature:

With hydrogen; 5%-palladium/activated carbon; In methanol; at 25 ℃; for 17h; under 1551.49 Torr;

Reference yield: 70.0%

4-Aminomethylpiperidine (7144-05-0) + tert-butyl 1H-imidazole-1-carboxylate (49761-82-2) → tert-butyl N-(4-piperidinylmethyl)carbamate (135632-53-0)

Guidance literature:

In toluene; at 25 ℃;

upstream raw materials:

di-tert-butyl dicarbonate

4-Aminomethylpiperidine

benzyl 4-(((tert-butoxycarbonyl)amino)methyl)piperidine-1-carboxylate

tert-butyl 1H-imidazole-1-carboxylate

Downstream raw materials:

[1-(4-aminobenzenesulfonyl)-piperidin-4-ylmethyl]-carbamic acid t-butyl ester

4-(4-bromo-2-fluorophenoxy)-7-[3-(4-tert-butoxycarbonylaminomethylpiperidin-1-yl)propoxy]-6-methoxyquinazoline

tert-butyl [{1-(2-benzyloxycarbonyl-2-methylpropyl)piperidin-4-yl}methyl]carbamate

C₁₆H₂₄N₆O₂

Refernces

• 1、 Ko?ak, Urban,Knez, Damijan,Brus, Boris,Pi?lar, Anja,Kos, Janko,Gobec, Stanislav,Coquelle, Nicolas,Colletier, Jacques-Philippe,Nachon, Florian,Brazzolotto, Xavier. "N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents". . p. 633 - 645. Retrieved 2016/12/30.
• 2、 -. "Autotaxin inhibitors". Page/Page column. . Retrieved 2014/06/25.