7H-Pyrrolo[3,2-f]quinazoline-1,3-diamine

Base Information

• Chemical Name: 7H-Pyrrolo[3,2-f]quinazoline-1,3-diamine
• CAS No.: 65795-37-1
• Molecular Formula: C10H9N5
• Molecular Weight: 199.212
• Hs Code.: 2933990090
• Mol file: 65795-37-1.mol

Synonyms:7H-Pyrrolo(3,2-f)quinazoline-1,3-diamine;TCMDC-124301;

Chemical Property of 7H-Pyrrolo[3,2-f]quinazoline-1,3-diamine

Chemical Property:

• Vapor Pressure: 2.67E-15mmHg at 25°C
• Refractive Index: 1.942
• Boiling Point: 620.1 °C at 760 mmHg
• PKA: 14.79±0.50(Predicted)
• Flash Point: 365.3 °C
• PSA: 93.61000
• Density: 1.568 g/cm³
• LogP: 2.43790

Purity/Quality:

99% ^*data from raw suppliers

7H-PYRROLO[3,2-F]QUINAZOLINE-1,3-DIAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7H-Pyrrolo[3,2-f]quinazoline-1,3-diamine

There total 6 articles about 7H-Pyrrolo[3,2-f]quinazoline-1,3-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

C10H9N5 → 1,3-diamino-7H-pyrrolo[3,2-f]quinazoline (65795-37-1)

Guidance literature:

With boron trifluoride; In 1,2-dimethoxyethane; at 60 ℃; for 4h;

DOI:10.1039/c3md00134b

Reference yield: 76.0%

N-cyano-N'-(1H-indol-5-yl)guanidine (150057-70-8) → 1,3-diamino-7H-pyrrolo[3,2-f]quinazoline (65795-37-1)

Guidance literature:

With boron trifluoride diethyl etherate; In 1,2-dimethoxyethane; at 60 ℃; for 1.5h;

Reference yield: 24.0%

(1,3-diamino-7H-pyrrolo[3,2-f]quinazolin-7-yl)ethanone → N-(3-amino-7H-pyrrolo[3,2-f]quinazolin-1-yl)acetamide + 1,3-diamino-7H-pyrrolo[3,2-f]quinazoline (65795-37-1)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; regioselective reaction;

upstream raw materials:

N-cyano-N'-(1H-indol-5-yl)guanidine

5-amino-1H-indole

N-cyano-N'-(1H-indol-5-yl)guanidine

Downstream raw materials:

7-[(2,4-Dichlorophenyl)methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine

7-(4-Carboxybenzyl)-7H-pyrrolo[3,2-f]-quinazoline-1,3-diamine, sodium salt

7-(4-ethoxy-benzyl)-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine

7-(4-tert-butyl-benzyl)-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine

Refernces

• 1、 Chen, Jingjin,Kassenbrock, Alina,Li, Bingbing X.,Xiao, Xiangshu. "Discovery of a potent anti-tumor agent through regioselective mono-N-acylation of 7H-pyrrolo[3,2-f]quinazoline-1,3-diamine". . p. 1275 - 1282. Retrieved 2013/09/12.
• 2、 Jones, Michael L.,Kuyper, Lee F.,Styles, Virgil L.,Caddell, J. Marc. "Lewis Acid Assisted Cyclization of Arylcyanoguanidines to 2,4-Diaminoquinazolines". . p. 1681 - 1684. Retrieved 2007/10/02.