Technology Process of Dapiramicin B
There total 9 articles about Dapiramicin B which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 2 steps
1: 55 percent / NaO(t-Bu) / Pd2(dba)3; (S)-BINAP / toluene / 6 h / 80 °C
2: 92 percent / BF3*OEt2 / CH2Cl2 / 0.5 h / 0 °C
With
boron trifluoride diethyl etherate; sodium t-butanolate;
tris(dibenzylideneacetone)dipalladium (0); (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine);
In
dichloromethane; toluene;
DOI:10.1016/j.tetlet.2006.06.001
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 41 percent / silicic acid; NaHCO3 / methanol; diethyl ether / sonication
2: 72 percent / SBr3; t-BuONO / various solvent(s) / 0 °C
3: 55 percent / NaO(t-Bu) / Pd2(dba)3; (S)-BINAP / toluene / 6 h / 80 °C
4: 92 percent / BF3*OEt2 / CH2Cl2 / 0.5 h / 0 °C
With
tert.-butylnitrite; boron trifluoride diethyl etherate; sodium hydrogencarbonate; silicic acid; sodium t-butanolate;
tris(dibenzylideneacetone)dipalladium (0); (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine);
In
methanol; diethyl ether; dichloromethane; toluene;
DOI:10.1016/j.tetlet.2006.06.001
