1-(1-PROPYNYL)CYCLOHEXANOL

Base Information

• Chemical Name: 1-(1-PROPYNYL)CYCLOHEXANOL
• CAS No.: 697-37-0
• Molecular Formula: C9H14O
• Molecular Weight: 138.21
• Hs Code.: 2906199090
• Mol file: 697-37-0.mol

Synonyms:1-(2-Propynyl)cyclohexanol;

Chemical Property of 1-(1-PROPYNYL)CYCLOHEXANOL

Chemical Property:

• Vapor Pressure: 0.0218mmHg at 25°C
• Melting Point: 47°C
• Refractive Index: 1.5
• Boiling Point: 92°C 10mm
• PKA: 13.28±0.20(Predicted)
• Flash Point: 91-92°C/10mm
• PSA: 20.23000
• Density: 0.98g/cm³
• LogP: 1.70490

Purity/Quality:

99% ^*data from raw suppliers

1-(1-PROPYNYL)CYCLOHEXANOL 95.00% ^*data from reagent suppliers

Safty Information:

• Statements: 10
• Safety Statements: 16-26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(1-PROPYNYL)CYCLOHEXANOL

There total 5 articles about 1-(1-PROPYNYL)CYCLOHEXANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

1-(prop-2-ynyl)cyclohexanol (19135-08-1) → 1-(1-propynyl)cyclohexanol (697-37-0)

Guidance literature:

With potassium superoxide; In dimethyl sulfoxide; at 60 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2015.07.075

Reference yield:

1-propynylmagnesium bromide (16466-97-0,13254-27-8) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 1-(1-propynyl)cyclohexanol (697-37-0)

Guidance literature:

With diethyl ether;

DOI:10.1021/jo01352a613 DOI:10.1002/ardp.19572900206

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + prop-1-yne (74-99-7) → 1-(1-propynyl)cyclohexanol (697-37-0)

Guidance literature:

Multistep reaction; (i) EtMgBr, THF, (ii) /BRN= 385735/;

upstream raw materials:

1-propynylmagnesium bromide

cyclohexanone

1-propynyl lithium

prop-1-yne

Downstream raw materials:

1-Propin-(1)-yl-cyclohexanol-carbamat

(Z)-1-(prop-1-en-1-yl)cyclohexan-1-ol

3-cyclohexylidene-N,N-dimethyl-2-methyl-2-propenamide

S-Methyl-S'-<1-cyclohexyliden-propen-(1)-yl-(2)>-dithiolcarbonat

Refernces

• 1、 Wei, Kai,Luo, Kai,Liu, Fang,Wu, Lei,Wu, Li-Zhu. "Visible-light-driven selective alkenyl C-P bond cleavage of allenylphosphine oxides". supporting information. p. 1994 - 1998. Retrieved 2019/03/29.
• 2、 Abrams, Roman,Lefebvre, Quentin,Clayden, Jonathan. "Transition Metal Free Cycloamination of Prenyl Carbamates and Ureas Promoted by Aryldiazonium Salts". supporting information. p. 13587 - 13591. Retrieved 2018/09/25.