1-[4-(4-Aminophenyl)phenyl]ethanone

Base Information

• Chemical Name: 1-[4-(4-Aminophenyl)phenyl]ethanone
• CAS No.: 1141-39-5
• Molecular Formula: C14H13NO
• Molecular Weight: 211.263
• Hs Code.: 2922399090
• NSC Number: 58062
• DSSTox Substance ID: DTXSID90288911
• Nikkaji Number: J1.542.289K
• Wikidata: Q82026053
• Mol file: 1141-39-5.mol

Synonyms:1-(4'-amino-biphenyl-4-yl)-ethanone

Chemical Property of 1-[4-(4-Aminophenyl)phenyl]ethanone

Chemical Property:

• Vapor Pressure: 9.98E-06mmHg at 25°C
• Refractive Index: 1.607
• Boiling Point: 371.9 °C at 760 mmHg
• Flash Point: 178.7 °C
• PSA: 43.09000
• Density: 1.12 g/cm³
• LogP: 3.71960
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 211.099714038
• Heavy Atom Count: 16
• Complexity: 235

Purity/Quality:

99% ^*data from raw suppliers

1-(4'-AMINO[1,1'-BIPHENYL]-4-YL)-ETHANONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C1=CC=C(C=C1)C2=CC=C(C=C2)N
• Use Description: 1-[4-(4-aminophenyl)phenyl]ethanone, a chemical compound, serves multiple roles in different fields. In the pharmaceutical industry, it can be used as an intermediate for synthesizing various drugs and pharmaceutical compounds, making it crucial for drug development. In materials science, this compound can find application as a building block for the production of polymers and plastics, contributing to the creation of advanced materials with tailored properties. Additionally, in the field of organic chemistry, it acts as a versatile reagent for the synthesis of complex organic molecules. Its role as an intermediate and reagent underscores its importance in pharmaceuticals, materials, and organic chemistry, making it a valuable compound in various scientific and industrial endeavors.

Technology Process of 1-[4-(4-Aminophenyl)phenyl]ethanone

There total 10 articles about 1-[4-(4-Aminophenyl)phenyl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-acetyl-4'-nitrobiphenyl (135-69-3) → 1-(4'-amino-biphenyl-4-yl)-ethanone (1141-39-5)

Guidance literature:

With hydrogenchloride; SnCl₃^(1-); In ethanol; for 1h; Heating;

DOI:10.1007/BF01184879

Reference yield: 67.0%

4-chloro-aniline (106-47-8) + 4-acetylphenylboronic acid (149104-90-5) → 1-(4'-amino-biphenyl-4-yl)-ethanone (1141-39-5)

Guidance literature:

With potassium carbonate; at 70 ℃;

DOI:10.1016/j.mcat.2021.111573

Reference yield: 65.0%

(4-aminophenyl)boronic acid (89415-43-0) + para-bromoacetophenone (99-90-1) → 1-(4'-amino-biphenyl-4-yl)-ethanone (1141-39-5)

Guidance literature:

With tetrabutylammomium bromide; potassium carbonate; quasi polymeric 4-pyridine-aldoxime Pd(II)-catalyst; at 120 ℃; for 0.333333h; microwave irradiation;

DOI:10.1055/s-2004-829546

upstream raw materials:

4-acetyl-4'-nitrobiphenyl

4-Iodoacetophenone

(4-aminophenyl)boronic acid

para-bromoacetophenone

Downstream raw materials:

1-(4'-benzylamino-biphenyl-4-yl)-ethanone

Refernces

• 1、 Hajipour, Abdol R.,Malek, Shaghayegh Sadeghi. "Magnetic chitosan-functionalized cobalt-NHC: Synthesis, characterization and catalytic activity toward Suzuki and Sonogashira cross-coupling reactions of aryl chlorides". . . Retrieved 2021/04/23.
• 2、 Mou, Jianfeng,Park, Ann,Cai, Yu,Yuan, Junying,Yuan, Chengye. "Structure-activity relationship study of E6 as a novel necroptosis inducer". supporting information. p. 3057 - 3061. Retrieved 2015/06/22.