N,N-Dimethyl-2,3,4,5,6-pentafluoroaniline

Base Information

• Chemical Name: N,N-Dimethyl-2,3,4,5,6-pentafluoroaniline
• CAS No.: 1801-14-5
• Molecular Formula: C8H6F5N
• Molecular Weight: 211.134
• Hs Code.: 2921420090
• Mol file: 1801-14-5.mol

Synonyms:Benzenamine,2,3,4,5,6-pentafluoro-N,N-dimethyl;N,N-Dimethyl-2,3,4,5,6-pentafluoroaniline;pentafluorophenyl-dimethylamine;N,N-dimethyl-pentafluoro-aniline;

Chemical Property of N,N-Dimethyl-2,3,4,5,6-pentafluoroaniline

Chemical Property:

• Vapor Pressure: 0.662mmHg at 25°C
• Boiling Point: 186.5°Cat760mmHg
• Flash Point: 66.6°C
• PSA: 3.24000
• Density: 1.422g/cm³
• LogP: 2.44810

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N-Dimethyl-2,3,4,5,6-pentafluoroaniline

There total 12 articles about N,N-Dimethyl-2,3,4,5,6-pentafluoroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

2,3,4,5,6-pentafluoroaniline (771-60-8) + methyl iodide (74-88-4) → 1-(N,N-dimethylamine)pentafluorobenzene (1801-14-5)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 0.166667h;

DOI:10.1002/chem.201000185

Reference yield: 21.0%

Hexafluorobenzene (392-56-3) + N-(1-ethoxyvinyl)-N,N-dimethylamine (816-65-9) → ethoxy pentafluorobenzene (776-39-6) + 1-(N,N-dimethylamine)pentafluorobenzene (1801-14-5)

Guidance literature:

for 10h; Heating;

Reference yield:

N,N,N,N,N,N-hexamethylphosphoric triamide (680-31-9) + Hexafluorobenzene (392-56-3) → dimefox (115-26-4) + 1-(N,N-dimethylamine)pentafluorobenzene (1801-14-5) + 2,3,5,6-tetrafluoro-N1,N1,N4,N4-tetramethyl-1,4-benzenediamine (2262-15-9) + 1,2,4-tri(N,N-dimethylamine)trifluorobenzene (2241-47-6)

Guidance literature:

at 160 ℃; for 82h; Further Variations:; Temperatures; time; Product distribution;

DOI:10.1016/j.jfluchem.2008.02.005

upstream raw materials:

Hexafluorobenzene

N-(1-ethoxyvinyl)-N,N-dimethylamine

dimethyl amine

2,3,4,5,6-pentafluoroaniline

Downstream raw materials:

2,3,4,5,6-pentafluoro-N,N-dimethylaniline N-oxide trifluoroacetic acid salt

4-Dimethylamino-1-methoxy-tetrafluor-benzol

N,N-dimethylamino-2,3,5,6-tetrafluorobenzene

bis(trifluoromethyl)pentafluorophenylamine

Refernces

• 1、 Weidlich, Frauke,Esumi, Naoto,Chen, Dongyang,Mück-Lichtenfeld, Christian,Zysman-Colman, Eli,Studer, Armido. "Mild C?F Activation in Perfluorinated Arenes through Photosensitized Insertion of Isonitriles at 350 nm". . p. 376 - 383. Retrieved 2019/11/19.
• 2、 Roberts, Kenneth M.,Jones, Jeffery P.. "Anilinic N-oxides support cytochrome P450-mediated N-dealkylation through hydrogen-atom transfer". experimental part. p. 8096 - 8107. Retrieved 2010/09/11.