Technology Process of Nemertelline
There total 4 articles about Nemertelline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 62 percent / 57-80percent m-chloroperbenzoic acid / CHCl3 / 24 h / Ambient temperature
2: 48 percent / Ac2O / 12 h / Heating
3: 32 percent / POCl3 / dimethylformamide / 18 h / Heating
4: 1.) Pd(PPh3)4, 2.) K2CO3 / 1.) THF, room temp., 5 min, 2.) THF, water, reflux, 24 h
With
tetrakis(triphenylphosphine) palladium(0); acetic anhydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate;
In
chloroform; N,N-dimethyl-formamide;
DOI:10.1016/0040-4020(95)00698-8
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 48 percent / Ac2O / 12 h / Heating
2: 32 percent / POCl3 / dimethylformamide / 18 h / Heating
3: 1.) Pd(PPh3)4, 2.) K2CO3 / 1.) THF, room temp., 5 min, 2.) THF, water, reflux, 24 h
With
tetrakis(triphenylphosphine) palladium(0); acetic anhydride; potassium carbonate; trichlorophosphate;
In
N,N-dimethyl-formamide;
DOI:10.1016/0040-4020(95)00698-8
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 32 percent / POCl3 / dimethylformamide / 18 h / Heating
2: 1.) Pd(PPh3)4, 2.) K2CO3 / 1.) THF, room temp., 5 min, 2.) THF, water, reflux, 24 h
With
tetrakis(triphenylphosphine) palladium(0); potassium carbonate; trichlorophosphate;
In
N,N-dimethyl-formamide;
DOI:10.1016/0040-4020(95)00698-8