7-METHOXY-1-INDANONE 97

Base Information

• Chemical Name: 7-METHOXY-1-INDANONE 97
• CAS No.: 34985-41-6
• Molecular Formula: C10H10 O2
• Molecular Weight: 162.188
• Hs Code.: 29145090
• Mol file: 34985-41-6.mol

Synonyms:1-Indanone,7-methoxy- (6CI,7CI);2,3-Dihydro-7-methoxy-1H-inden-1-one;7-Methoxy-1-indanone;7-Methoxyhydrindone;7-Methoxyindan-2-one;NSC 148876;

Chemical Property of 7-METHOXY-1-INDANONE 97

Chemical Property:

• Vapor Pressure: 0.000826mmHg at 25°C
• Melting Point: 99-102 °C
• Refractive Index: 1.564
• Boiling Point: 305.3°Cat760mmHg
• Flash Point: 147°C
• PSA: 26.30000
• Density: 1.166g/cm³
• LogP: 1.82410
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

7-Methoxy-2,3-dihydro-1H-inden-1-one ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-36-43
• Safety Statements: 26-36

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Uses: 7-Methoxy-1-indanone can be used to synthesize 10,15-Dihydro-4,9,14-trimethoxy-5H-diindeno[1,2-a;1′,2′-c]fluorene via acid-catalyzed trimerization.

Technology Process of 7-METHOXY-1-INDANONE 97

There total 9 articles about 7-METHOXY-1-INDANONE 97 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

3-(3-Methoxy-phenyl)-propionic acid (10516-71-9) → 7-methoxy-indan-1-one (34985-41-6) + 5-methoxy-1-indanone (5111-70-6)

Guidance literature:

With trifluorormethanesulfonic acid; In dichloromethane; at 80 ℃; for 1h; High pressure; Inert atmosphere; Green chemistry;

DOI:10.3390/molecules19055599

Reference yield: 52.0%

carbon monoxide (201230-82-2) + 3-(trimethylsilylethynyl)anisole (40230-92-0) → 7-methoxy-indan-1-one (34985-41-6) + 5-methoxy-1-indanone (5111-70-6)

Guidance literature:

With water; triethylamine; triphenylphosphine; chloro(1,5-cyclooctadiene)rhodium(I) dimer; In tetrahydrofuran; at 160 ℃; for 4h; under 51485.6 Torr;

DOI:10.1021/jo00072a020

Reference yield: 42.0%

4,6-dibromo-7-methoxy-2,3-dihydro-1H-inden-1-one (125714-97-8) → 7-methoxy-indan-1-one (34985-41-6) + 6-bromo-7-methoxy-2,3-dihydro-1H-inden-1-one (1273599-65-7)

Guidance literature:

With triethylsilane; palladium diacetate; In acetonitrile; at 150 ℃; for 0.5h; Reagent/catalyst; Temperature; regioselective reaction; Catalytic behavior; Inert atmosphere; Sealed tube; Microwave irradiation;

DOI:10.1002/ejoc.201901351

upstream raw materials:

carbon monoxide

3-(trimethylsilylethynyl)anisole

3-(3-Methoxy-phenyl)-propionic acid

3-methoxy-benzaldehyde

Downstream raw materials:

8-methoxy-3,4-dihydroisoquinolin-1(2H)-one

7a-benzyl-7-methoxy-2,3,5,7a-tetrahydro-1H-inden-1-one

4-methoxyindan-2-carboxylic acid

methyl 2-acetyl-3-hydroxybenzeneacetate

Refernces

• 1、 Oliverio, Manuela,Nardi, Monica,Costanzo, Paola,Cariati, Luca,Cravotto, Giancarlo,Giofre, Salvatore Vincenzo,Procopio, Antonio. "Non-conventional methodologies in the synthesis of 1-indanones". . p. 5599 - 5610. Retrieved 2014/06/10.
• 2、 Barlow, James W.,Walsh, John J.. "Synthesis and evaluation of dimeric 1,2,3,4-Tetrahydro-naphthalenylamine and Indan-1-ylamine derivatives with mast cell-stabilising and anti-allergic activity". scheme or table. p. 25 - 37. Retrieved 2010/03/04.