Dimethyl-beta-cyclodextrin

Base Information

• Chemical Name: Dimethyl-beta-cyclodextrin
• CAS No.: 128446-36-6
• Deprecated CAS: 1686114-48-6
• Molecular Formula: C56H98O35
• Molecular Weight: 1331.36
• Hs Code.: 35051000
• Mol file: 128446-36-6.mol

Synonyms:2,6-beta-O-dimethylcyclodextrin;2,6-di-O-methyl-beta-cyclodextrin;dimethyl-beta-cyclodextrin;DM-beta-CD;DM-beta-CyD;DMbeta-Cyd;heptakis(2,6-di-O-methyl)-beta-cyclodextrin;heptakis(2,6-O-dimethyl)beta-cyclodextrin;HKDBC;MEDCD cpd

Chemical Property of Dimethyl-beta-cyclodextrin

Chemical Property:

• Appearance/Colour: white to off-powder
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 180-182 °C(lit.)
• Refractive Index: 1.552
• Boiling Point: 1206.9±65.0 °C at 760 mmHg
• Flash Point: 683.7±34.3 °C
• PSA: 422.05000
• Density: 1.4 g/cm³
• LogP: -7.38140
• Storage Temp.: room temp
• Solubility.: H2O: soluble50mg/mL
• Water Solubility.: Soluble in water
• XLogP3: -7.5
• Hydrogen Bond Donor Count: 7
• Hydrogen Bond Acceptor Count: 35
• Rotatable Bond Count: 21
• Exact Mass: 1330.5888648
• Heavy Atom Count: 91
• Complexity: 1690

Purity/Quality:

99% ^*data from raw suppliers

Methyl-b-cyclodextrin ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COCC1C2C(C(C(O1)OC3C(OC(C(C3O)OC)OC4C(OC(C(C4O)OC)OC5C(OC(C(C5O)OC)OC6C(OC(C(C6O)OC)OC7C(OC(C(C7O)OC)OC8C(OC(O2)C(C8O)OC)COC)COC)COC)COC)COC)COC)OC)O
• Description: Methyl-β-cyclodextrin is a randomly methylated form of the cyclic oligosaccharide β-cyclodextrin . Methyl-β-cyclodextrin contains seven D-(+)-glucopyranose units that contain randomized hydrogen or methyl groups. Methyl-β-cyclodextrin has been used to improve the aqueous solubility of various compounds and to extract cholesterol from lipid membranes. Methyl-β-cyclodextrin (5 mM) reduces α-synuclein levels in the membrane and detergent-insoluble fractions from B103 neuroblastoma cells transfected with human α-synuclein. It also reduces α-synuclein levels in mouse brain in a transgenic model of α-synucleinopathy.
• Uses: substrate for laminarinase and other glucanases Cavity size is the major determinant as to which cyclodextrin is used in complexation. The cavity diameter of β-cyclodextrins or β-glucopyranose unit compounds is well-suited for use with molecules the size of hormones, vitamins and many compounds frequently used in tissue and cell culture applications. For this reason, β-cyclodextrin is most commonly used as a complexing agent. It is used to increase the solubility of non-polar substances such as fatty acids, lipids, vitamins and cholesterol for use in cell culture applications. Methyl-β-cyclodextrin is used to remove cholesterol from cultured cells and is employed to remove lipid rafts. Methyl-β-cyclodextrin is a cholesterol-removing agent mainly used for lipid raft disruption. It may also be used for detergent removal from protein-lipid-detergent ternary mixture to produce 2D membrane protein crystals due to its high solubility and affinity for detergents generally used in membrane protein chemistry.