3-AMINO-CIS-DIMETHYLPIPERIDINE

Base Information

• Chemical Name: 3-AMINO-CIS-DIMETHYLPIPERIDINE
• CAS No.: 61147-58-8
• Molecular Formula: C7H16N2
• Molecular Weight: 128.217
• Hs Code.: 2933399090
• Mol file: 61147-58-8.mol

Synonyms:1-Piperidinamine,2,6-dimethyl-, cis-;1-Amino-cis-2,6-dimethylpiperidine;NSC 223068;cis-1-Amino-2,6-dimethylpiperidine;cis-2,6-Dimethyl-1-piperidinamine;

Chemical Property of 3-AMINO-CIS-DIMETHYLPIPERIDINE

Chemical Property:

• Vapor Pressure: 2.45mmHg at 25°C
• Refractive Index: n20/D 1.464
• Boiling Point: 159.9 °C at 760 mmHg
• Flash Point: 42.2 °C
• PSA: 29.26000
• Density: 0.883 g/cm³
• LogP: 1.76120

Purity/Quality:

99% ^*data from raw suppliers

1-Amino-cis-2,6-dimethylpiperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 10-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-AMINO-CIS-DIMETHYLPIPERIDINE

There total 5 articles about 3-AMINO-CIS-DIMETHYLPIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 1-Amino-trans-2,6-dimethyl-piperidin (39135-39-2,61147-58-8)

Guidance literature:

Eintragen von wss. Eg. in eine Mischung von 1-Nitroso-trans-2,6-dimethyl-piperidin in W. u. Zinkstaub (anfangs unter Kuehlung, zuletzt bei 100grad);

DOI:10.1002/hlca.19620450705

Reference yield:

cis-2,6-dimethyl-1-nitrosopiperidine (16642-61-8) → 2,6-cis-dimethyl-1-amino-piperidine (61147-58-8)

Guidance literature:

With lithium aluminium tetrahydride; diethyl ether;

DOI:10.1021/ja01620a040

Reference yield:

2,6-dimethylpyridine (108-48-5) → 2,6-cis-dimethyl-1-amino-piperidine (61147-58-8)

Guidance literature:

Multi-step reaction with 3 steps

1: rhodium/ aluminium oxide; acetic acid / 60 °C / Hydrogenation

2: aqueous hydrochloric acid; sodium nitrite

3: lithium alanate; diethyl ether

With hydrogenchloride; Rh/Al₂O₃; lithium aluminium tetrahydride; diethyl ether; acetic acid; sodium nitrite;

DOI:10.1021/ja01620a040

upstream raw materials:

cis-2,6-dimethyl-1-nitrosopiperidine

2,6-dimethylpyridine

(2R,6S)-2,6-dimethylpiperidine

Downstream raw materials:

(4S,5S)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-(cis-2,6-dimethylpiperidin-1-yl)-4-methyl-4,5-dihydro-1H-pyrazole-3-carboxamide