2,3,5-Trichloroanisole

Base Information

• Chemical Name: 2,3,5-Trichloroanisole
• CAS No.: 54135-81-8
• Molecular Formula: C7H5 Cl3 O
• Molecular Weight: 211.475
• Hs Code.: 2909309090
• Nikkaji Number: J530.293E
• Mol file: 54135-81-8.mol

Synonyms:2,3,5-TRICHLOROANISOLE;1,2,5-Trichloro-3-methoxybenzene;2,3,5-Trichloranisol;SCHEMBL9563947;1,2,5-Trichloro-3-methoxy-benzene;1,2,5-Trichloro-3-methoxybenzene #;Benzene, 1,2,4-trichloro-6-methoxy

Chemical Property of 2,3,5-Trichloroanisole

Chemical Property:

• Vapor Pressure: 0.000532mmHg at 25°C
• Boiling Point: 299.4°Cat760mmHg
• Flash Point: 134.9°C
• PSA: 9.23000
• Density: 1.52g/cm³
• LogP: 3.65540
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 209.940598
• Heavy Atom Count: 11
• Complexity: 131

Purity/Quality:

99%min ^*data from raw suppliers

(2,3,5-Trichloro-phenyl)-methanol 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C(=CC(=C1)Cl)Cl)Cl

Technology Process of 2,3,5-Trichloroanisole

There total 11 articles about 2,3,5-Trichloroanisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

1,2,3,5-tetrachlorobenzene (634-90-2) + sodium methylate (124-41-4) → 2,4,6-trichloroanisole (87-40-1) + 2,3,5-trichloroanisole (54135-81-8)

Guidance literature:

In N,N,N,N,N,N-hexamethylphosphoric triamide; at 120 ℃; for 1h;

DOI:10.1016/S0040-4020(01)97647-1

Reference yield:

1,2,3,5-tetrachlorobenzene (634-90-2) → 2,3,5-trichlorophenol (933-78-8) + 2,3,5-trichloroanisole (54135-81-8)

Guidance literature:

With sodium methylate; at 180 ℃; im Rohr;

Reference yield:

1,2,3,5-tetrachlorobenzene (634-90-2) + sodium methylate (124-41-4) → 2,3,5-trichlorophenol (933-78-8) + 2,3,5-trichloroanisole (54135-81-8)

Guidance literature:

at 176 - 180 ℃; Kinetics; im Rohr;

upstream raw materials:

1,2,3,5-tetrachlorobenzene

sodium methylate

3-chloro-2-nitroanisole

2,3,5-trichlorophenol

Downstream raw materials:

O-methylresorcine

2,3,5-trichlorophenol

1,2-dichloro-3,5-dimethoxybenzene

2,5-dichloro-1,3-dimethoxybenzene

Refernces

• 1、 Bolton, Roger,Moore, Clive,Sandall, John P.B.. "Nucleophilic Displacement in Polyhalogenoaromatic Compounds. Part 11. Kinetics of Protiodeiodination of Iodoarenes in Dimethyl Sulphoxide-Methanol". . p. 1593 - 1598. Retrieved 2007/10/02.