11H-pyrido(2,1-b)quinazolin-11-one

Base Information

• Chemical Name: 11H-pyrido(2,1-b)quinazolin-11-one
• CAS No.: 578-96-1
• Molecular Formula: C12H8 N2 O
• Molecular Weight: 196.208
• Hs Code.: 2933990090
• Mol file: 578-96-1.mol

Synonyms:11H-pyrido(2,1-b)quinazolin-11-one

Chemical Property of 11H-pyrido(2,1-b)quinazolin-11-one

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 211-212 ºC
• Boiling Point: 376.9°Cat760mmHg
• Flash Point: 181.7°C
• PSA: 34.37000
• Density: 1.28
• LogP: 1.84770

Purity/Quality:

99% ^*data from raw suppliers

11H-PYRIDO-[2,1-B]QUINAZOLIN-11-ONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 11H-pyrido(2,1-b)quinazolin-11-one

There total 8 articles about 11H-pyrido(2,1-b)quinazolin-11-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2,3-dichloro-pyridine (2402-77-9) + 2-ethoxycarbonylaniline (87-25-2) → ethyl 2-[(3-chloropyridin-2-yl)amino]benzoate (1163681-49-9) + 11H-pyrido[2,1-b]quinazolin-11-one (578-96-1)

Guidance literature:

With palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; for 18h; regioselective reaction; Reflux;

DOI:10.1002/adsc.200800077

Reference yield: 68.0%

2-chloropyridine (109-09-1) + indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) → tryptanthrine (13220-57-0) + 11H-pyrido[2,1-b]quinazolin-11-one (578-96-1)

Guidance literature:

With copper(II) acetate monohydrate; sodium hydrogencarbonate; In water; N,N-dimethyl-formamide; at 120 ℃; for 2h;

DOI:10.1021/acs.orglett.6b00113

Reference yield: 49.0%

2-(2-bromophenyl)-N-(pyridin-2-yl)acetamide (1446208-21-4) → 2-(2-bromophenyl)-2-oxo-N-(pyridin-2-yl)acetamide (1609551-62-3) + 11H-pyrido[2,1-b]quinazolin-11-one (578-96-1)

Guidance literature:

With copper(l) iodide; 1,10-Phenanthroline; tetrabutylammomium bromide; potassium acetate; In 1,4-dioxane; at 80 ℃; for 6h;

DOI:10.1002/adsc.201300818

upstream raw materials:

2-chloropyridine

anthranilic acid

2,1-benzisothiazolin-3(1H)-one

2,1-benzisothiazoline-3-spiro-2',4'-oxo-4'H-3',1'-benzoxazolidine

Downstream raw materials:

1,2,3,4-tetrahydro-quinazoline-2,4-dione

3-(2-(pyridin-2-ylamino)phenyl)pentan-3-ol

(2-(pyridin-2-ylamino)phenyl)methanol

6-phenylhydrazono-6,7,8,9-tetrahydro-11H-pyrido<2,1-b>quinazolin-11-one

Refernces

• 1、 Sun, Jie,Tan, Qitao,Yang, Wusong,Liu, Bingxin,Xu, Bin. "Copper-catalyzed aerobic oxidative annulation and carbon-carbon bond cleavage of arylacetamides: Domino synthesis of fused quinazolinones". supporting information. p. 388 - 394. Retrieved 2014/05/20.
• 2、 Davis, Michael,Hook, Robert J.,Wu, Wen Yang. "2,1-Benzisothiazoles. XIII . Intermediates and Products in the Sulfur Extrusion Reaction of 2,1-Benzisothiazolines-3(1H)-one. A New Synthesis of 11H-Pyridoquinazolin-11-one ("Pyracridone")". . p. 369 - 373. Retrieved 2007/10/02.