n-(3-Methylpyridin-2-yl)formamide

Base Information

• Chemical Name: n-(3-Methylpyridin-2-yl)formamide
• CAS No.: 4931-46-8
• Molecular Formula: C7H8N2O
• Molecular Weight: 136.153
• European Community (EC) Number: 659-415-6
• NSC Number: 44089
• Mol file: 4931-46-8.mol

Synonyms:n-(3-methylpyridin-2-yl)formamide;4931-46-8;NSC44089;3-methyl-2-pyridinylformamide;3-methyl-2-formylaminopyridine;SCHEMBL4857851;SCHEMBL9801015;VVSSRZAVOQVJHG-UHFFFAOYSA-N;N-(3-methyl-2-pyridinyl)formamide;NSC-44089;AKOS006351300

Chemical Property of n-(3-Methylpyridin-2-yl)formamide

Chemical Property:

• Vapor Pressure: 0.00017mmHg at 25°C
• Boiling Point: 330.1°Cat760mmHg
• Flash Point: 153.4°C
• Density: 1.176g/cm³
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 136.063662883
• Heavy Atom Count: 10
• Complexity: 116

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(N=CC=C1)NC=O

Technology Process of n-(3-Methylpyridin-2-yl)formamide

There total 7 articles about n-(3-Methylpyridin-2-yl)formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-methylpyridin-2-ylamine (1603-40-3) + formaldehyd (50-00-0,30525-89-4,61233-19-0) → N-(3-methyl-2-pyridinyl)formamide (4931-46-8)

Guidance literature:

With acetic anhydride; In ethyl acetate; at 25 - 48 ℃;

DOI:10.1016/j.bmcl.2017.01.002

Reference yield: 85.0%

Ketene (463-51-4) + (E)-ethyl-N-<2-(3-methylpyridyl)>iminomethyl ether (99790-38-2) → N-(3-methyl-2-pyridinyl)formamide (4931-46-8) + 9-methyl-4H-pyrido[1,2-a]pyrimidin-4-one (23443-12-1)

Guidance literature:

at 75 ℃; for 0.5h;

Reference yield: 44.0%

3-methylpyridin-2-ylamine (1603-40-3) + n-butyl formate (592-84-7) → N-(3-methyl-2-pyridinyl)formamide (4931-46-8)

Guidance literature:

at 107 ℃; for 16h;

DOI:10.1016/S0022-328X(96)06846-5

upstream raw materials:

3-methylpyridin-2-ylamine

formyl acetic anhydride

Ketene

(E)-ethyl-N-<2-(3-methylpyridyl)>iminomethyl ether

Downstream raw materials:

7-Azaindole

1-[(2-chloro-5-thiazolyl)methyl]-3-(3,5-dichlorophenyl)-2-hydroxy-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidinium inner salt

2-cyano-3-methylpyridine

Refernces

• 1、 Van Der Heijden, Gydo,Jong,Ruijter, Eelco,Orru, Romano V. A.. "2-Bromo-6-isocyanopyridine as a Universal Convertible Isocyanide for Multicomponent Chemistry". supporting information. p. 984 - 987. Retrieved 2016/03/15.
• 2、 Van Zandt, Michael C.,Doan, Brian,Sawicki, Diane R.,Sredy, Janet,Podjarny, Alberto D.. "Discovery of [3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl] acetic acids as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications". supporting information; experimental part. p. 2006 - 2008. Retrieved 2009/11/30.