4-HYDRAZINOCARBONYL-BENZENE-SULFONAMIDE

Base Information

• Chemical Name: 4-HYDRAZINOCARBONYL-BENZENE-SULFONAMIDE
• CAS No.: 35264-29-0
• Molecular Formula: C7H9 N3 O3 S
• Molecular Weight: 215.233
• Hs Code.: 2935009090
• Mol file: 35264-29-0.mol

Synonyms:Benzoicacid, p-sulfamoyl-, hydrazide (6CI,7CI); (4-Sulfamoylbenzoyl)hydrazine;4-Sulfamoylbenzohydrazide; 4-Sulfamoylbenzoic acid hydrazide; NSC 252930;p-Sulfamoylbenzoyl hydrazide; p-Sulfonamidobenzoic acid hydrazide

Chemical Property of 4-HYDRAZINOCARBONYL-BENZENE-SULFONAMIDE

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 123.66000
• Density: 1.475g/cm³
• LogP: 1.80980
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

4-(Hydrazinecarbonyl)benzenesulfonamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-HYDRAZINOCARBONYL-BENZENE-SULFONAMIDE

There total 6 articles about 4-HYDRAZINOCARBONYL-BENZENE-SULFONAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methyl 4-sulfamoylbenzoate (22808-73-7) → 4-(hydrazinecarbonyl)benzene-1-sulfonamide (35264-29-0)

Guidance literature:

With hydrazine hydrate; In 1,4-dioxane; at 100 ℃; for 8h;

DOI:10.1016/j.ejmech.2018.07.019

Reference yield: 41.0%

4-nitrophenyl 4-sulfamoylbenzoate → 4-(hydrazinecarbonyl)benzene-1-sulfonamide (35264-29-0)

Guidance literature:

With hydrazine hydrate; In ethanol; N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.1002/chem.202005115

Reference yield:

4-(aminosulfonyl)-benzoic acid (138-41-0) → 4-(hydrazinecarbonyl)benzene-1-sulfonamide (35264-29-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / SOCl₂ / 2 h / 20 °C

2: 67 percent / NH₂NH₂*H₂O / methanol / 3 h / 20 °C

With thionyl chloride; hydrazine hydrate; In methanol;

DOI:10.1021/ja057926x

upstream raw materials:

4-sulfamoylbenzoic acid ethyl ester

methyl 4-sulfamoylbenzoate

4-(aminosulfonyl)-benzoic acid

toluene-4-sulfonamide

Downstream raw materials:

C₈H₈N₃O₃S₃^(1-)*K⁽¹⁺⁾

2-[4-(aminosulfonyl)benzoyl]-N-[4-(aminosulfonyl)phenyl]-1-hydrazinecarbothioamide

4-{3-[4-(aminosulfonyl)phenyl]-5-thioxo-1,5-dihydro-4H-1,2,4-triazol-4-yl}benzenesulfonamide

4-(4-amino-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)benzenesulfonamide

Refernces

• 1、 Eldeeb, Assem H.,Abo-Ashour, Mahmoud F.,Angeli, Andrea,Bonardi, Alessandro,Lasheen, Deena S.,Elrazaz, Eman Z.,Nocentini, Alessio,Gratteri, Paola,Abdel-Aziz, Hatem A.,Supuran, Claudiu T.. "Novel benzenesulfonamides aryl and arylsulfone conjugates adopting tail/dual tail approaches: Synthesis, carbonic anhydrase inhibitory activity and molecular modeling studies". supporting information. . Retrieved 2021/05/10.
• 2、 van der Zouwen, Antonie J.,Jeucken, Aike,Steneker, Roy,Hohmann, Katharina F.,Lohse, Jonas,Slotboom, Dirk J.,Witte, Martin D.. "Iminoboronates as Dual-Purpose Linkers in Chemical Probe Development". . p. 3292 - 3296. Retrieved 2021/01/20.