Iodoacetic anhydride

Base Information

• Chemical Name: Iodoacetic anhydride
• CAS No.: 54907-61-8
• Molecular Formula: C4H4 I2 O3
• Molecular Weight: 353.883
• Hs Code.: 2915900090
• European Community (EC) Number: 625-989-1
• DSSTox Substance ID: DTXSID10970240
• Nikkaji Number: J364.690D
• Wikidata: Q82953385
• Mol file: 54907-61-8.mol

Synonyms:iodoacetic anhydride

Chemical Property of Iodoacetic anhydride

Chemical Property:

• Vapor Pressure: 0.00468mmHg at 25°C
• Melting Point: 47-49 °C(lit.)
• Boiling Point: 276.9oC at 760 mmHg
• Flash Point: >230 °F
• PSA: 43.37000
• Density: 2.664g/cm3
• LogP: 0.92620
• Storage Temp.: 2-8°C
• Solubility.: chloroform: soluble10%, clear to slightly hazy, yellow (pink or
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 353.82499
• Heavy Atom Count: 9
• Complexity: 109

Purity/Quality:

98%,99%, ^*data from raw suppliers

IodoaceticAcidAnhydride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T,C
• Hazard Codes: T,C
• Statements: 25-35
• Safety Statements: 22-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Other Classes -> Acid Anhydrides, Other
• Canonical SMILES: C(C(=O)OC(=O)CI)I
• Uses: Reagent used as linker for development of reagents used for differential protein quantitation via ion scanningReactant used for:Sythesis of N-iodoacetyl glycosylamine derivatives and converting amino precursors to IA derivativesLinking lysine residues to N-terminal α-amino groups of peptidesCapping amines and yielding a thiol reactive iodo-derivativeIodoacetylation

Technology Process of Iodoacetic anhydride

There total 5 articles about Iodoacetic anhydride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Iodoacetic acid (64-69-7) → iodoacetic anhydride (54907-61-8)

Guidance literature:

With dicyclohexyl-carbodiimide; In acetonitrile;

DOI:10.1039/ft9938903261

Reference yield:

Iodoacetic acid (64-69-7) → 2-iodoacetyl chloride (38020-81-4) + iodoacetic anhydride (54907-61-8)

Guidance literature:

With thionyl chloride; at 45 - 50 ℃;

Reference yield:

2-iodoacetyl chloride (38020-81-4) → iodoacetic anhydride (54907-61-8)

Guidance literature:

beim Aufbewahren in lose verschlossenen Flaschen;

upstream raw materials:

2-iodoacetyl chloride

Iodoacetic acid

thionyl chloride

Downstream raw materials:

[4-(2-iodo-acetylamino)-phenyl]-arsonic acid

2-iodo-N-1,10-phenanthrolin-5-ylacetamide

4-iodoacetylaminobenzoic acid

iodacetamide

Refernces

• 1、 Lecomte, J-P.,Mesmaeker, A. Kirsch-De,Demeunynck, M.,Lhomme, J.. "Synthesis and Characterisation of a New DNA-binding Bifunctional Ruthenium(II) Complex". . p. 3261 - 3269. Retrieved 2007/10/02.