Technology Process of N-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]-N-methylhydroxylamine
There total 4 articles about N-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]-N-methylhydroxylamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
at -78 ℃;
for 24h;
Inert atmosphere;
DOI:10.1124/dmd.110.032391
- Guidance literature:
-
desipramine;
at 37 ℃;
for 0.05h;
aq. phosphate buffer;
Enzymatic reaction;
With
NADPH;
aq. phosphate buffer;
DOI:10.1124/dmd.110.032391
- Guidance literature:
-
Multi-step reaction with 2 steps
1: methanol / 20 °C
2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / -78 °C / Inert atmosphere
With
3-chloro-benzenecarboperoxoic acid;
In
methanol; dichloromethane;
2: Cope elimination;
DOI:10.1124/dmd.110.032391
