2-Bromobenzohydrazide

Base Information

• Chemical Name: 2-Bromobenzohydrazide
• CAS No.: 29418-67-5
• Molecular Formula: C7H7BrN2O
• Molecular Weight: 215.049
• Hs Code.: 2928000090
• European Community (EC) Number: 249-614-2
• NSC Number: 522536
• DSSTox Substance ID: DTXSID90183634
• Nikkaji Number: J250.835D
• Mol file: 29418-67-5.mol

Synonyms:2-Bromobenzohydrazide;2-Bromobenzhydrazide;29418-67-5;2-Bromobenzoic hydrazide;2-bromobenzoic acid hydrazide;116921-73-4;EINECS 249-614-2;MFCD00051577;Benzoic acid, bromo-, hydrazide (9CI);(2-bromobenzoyl)hydrazine;2-BROMO-BENZOIC ACID HYDRAZIDE;bromobenzhydrazide;Benzoic acid, 2-bromo-, hydrazide;NSC522536;2-Bromobenzoylhydrazine;2-bromanylbenzohydrazide;SCHEMBL406053;2-bromobenzoic acid, hydrazide;DTXSID90183634;BBL008389;STK229692;AKOS000195579;NSC 522536;NSC-522536;VS-01900;CS-0192056;FT-0611531;FT-0611532;EN300-17220;D89049;A819898;SR-01000041089;SR-01000041089-1;Z56899129;F0722-1729

Chemical Property of 2-Bromobenzohydrazide

Chemical Property:

• Vapor Pressure: 4.87E-06mmHg at 25°C
• Melting Point: 152-154°C
• Refractive Index: 1.615
• Boiling Point: 367.2 °C at 760 mmHg
• PKA: 11.92±0.10(Predicted)
• Flash Point: 175.9 °C
• PSA: 55.12000
• Density: 1.615 g/cm³
• LogP: 2.14380
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: soluble in Methanol
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 213.97418
• Heavy Atom Count: 11
• Complexity: 151

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Bromobenzhydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:Irritating to eyes, respiratory system and skin.
• Hazard Codes: R36/37/38:Irritating to eyes, respiratory system and skin.
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(=O)NN)Br

Technology Process of 2-Bromobenzohydrazide

There total 8 articles about 2-Bromobenzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-bromobenzoic acid methyl ester (610-94-6) → 2-bromobenzohydrazide (29418-67-5)

Guidance literature:

With hydrazine hydrate; In ethanol;

DOI:10.1016/j.bmc.2005.05.011

Reference yield: 86.0%

2-bromobenzoic acid ethyl ester (6091-64-1) → 2-bromobenzohydrazide (29418-67-5)

Guidance literature:

With hydrazine hydrate; In ethanol; for 10.25h; Cooling with ice; Reflux;

Reference yield: 84.0%

2-bromobenzoic-acid (88-65-3) → 2-bromobenzohydrazide (29418-67-5)

Guidance literature:

2-bromobenzoic-acid; With sulfuric acid; In ethanol; for 6h; Reflux;

With hydrazine hydrate; sodium hydrogencarbonate; acetic acid; Reflux;

DOI:10.1016/j.ejmech.2017.06.036

upstream raw materials:

2-bromobenzoic acid ethyl ester

2-bromobenzoic-acid

2-bromobenzoic acid methyl ester

2-bromobenzoic acid chloride

Downstream raw materials:

furfural-(2-bromo-benzoylhydrazone)

2-bromo-benzoyl azide

ortho-bromobenzaldehyde

2-bromo-benzoic acid benzylidenehydrazide

Refernces

• 1、 Bai, Li-Ping,Guo, Yong,Jiang, Zhi-Hong,Liu, Jia-Zheng,Meng, Jie-Ru,Xu, Ting,Zheng, Zhi-Yuan. "Synthesis and biological evaluation of honokiol derivatives bearing 3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)oxazol-2(3h)-ones as potential viral entry inhibitors against sars-cov-2". . . Retrieved 2021/09/08.
• 2、 -. "Oxazole ring-containing honokiol thioether derivative and preparation method and application thereof". Paragraph 0042; 0045-0046. . Retrieved 2021/08/11.