Lorazepam acetate

Base Information

• Chemical Name: Lorazepam acetate
• CAS No.: 2848-96-6
• Molecular Formula: C17H12Cl2N2O3
• Molecular Weight: 363.2
• Hs Code.: 2933997500
• European Community (EC) Number: 220-653-7
• UNII: Y4HA6DWZ18
• DSSTox Substance ID: DTXSID00951169
• Nikkaji Number: J306.777G
• Wikidata: Q27294252
• ChEMBL ID: CHEMBL507764
• Mol file: 2848-96-6.mol

Synonyms:lorazepam acetate;lorazepam acetate, (+-)-isomer;lorazepam acetate, (R)-isomer;lorazepam acetate, (S)-isomer;lorazepam acetate, 2-(14)C-labeled

Chemical Property of Lorazepam acetate

Chemical Property:

• Vapor Pressure: 4.33E-11mmHg at 25°C
• Refractive Index: 1.656
• Boiling Point: 524.4 °C at 760 mmHg
• Flash Point: 270.9 °C
• PSA: 67.76000
• Density: 1.45 g/cm³
• LogP: 3.24570
• XLogP3: 3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 362.0224976
• Heavy Atom Count: 24
• Complexity: 540

Purity/Quality:

99.9% ^*data from raw suppliers

Lorazepam Related Compound A United States Pharmacopeia (USP) Reference Standard ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,N
• Hazard Codes: Xn,N
• Statements: 22-50/53
• Safety Statements: 60-61

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)OC1C(=O)NC2=C(C=C(C=C2)Cl)C(=N1)C3=CC=CC=C3Cl

Technology Process of Lorazepam acetate

There total 6 articles about Lorazepam acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.4%

potassium acetate (127-08-2) + delorazepam (2894-67-9) → 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2-oxo-2H-1,4-benzodiazepin-3-yl acetate (2848-96-6,84799-34-8)

Guidance literature:

With dipotassium peroxodisulfate; iodine; In acetic acid; at 65 - 70 ℃; for 5.5h; Reagent/catalyst; Temperature; Time; Large scale;

DOI:10.1021/op068009u

Reference yield: 79.1%

acetic acid (64-19-7,77671-22-8) + delorazepam (2894-67-9) → 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2-oxo-2H-1,4-benzodiazepin-3-yl acetate (2848-96-6,84799-34-8)

Guidance literature:

With dipotassium peroxodisulfate; iodine; potassium acetate; at 80 ℃; for 7h; Temperature;

Reference yield:

potassium acetate (127-08-2) + acetic acid (64-19-7,77671-22-8) + delorazepam (2894-67-9) → 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2-oxo-2H-1,4-benzodiazepin-3-yl acetate (2848-96-6,84799-34-8)

Guidance literature:

With dipotassium peroxodisulfate; iodine; at 80 ℃; for 7h; Temperature;

upstream raw materials:

potassium acetate

delorazepam

(2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone

2-chloroacetamido-2’,5-dichlorobenzophenone

Downstream raw materials:

lorazepam-α-methyl-β-phenyl-propionate

lorazepam-α-chloro-propionate

lorazepam-β-phenyl-propionate

lorazepam

Refernces

• 1、 -. "Method for preparing lorazepam". Paragraph 0069-0071; 0076-0078; 0083-0085; 0090-0092. . Retrieved 2020/02/29.
• 2、 Cheng, Pi,Zhang, Quan,Ma, Yun-Bao,Jiang, Zhi-Yong,Zhang, Xue-Mei,Zhang, Feng-Xue,Chen, Ji-Jun. "Synthesis and in vitro anti-hepatitis B virus activities of 4-aryl-6-chloro-quinolin-2-one and 5-aryl-7-chloro-1,4-benzodiazepine derivatives". supporting information; scheme or table. p. 3787 - 3789. Retrieved 2009/04/06.