(2S)-2-Methoxy-1-propanol

Base Information

• Chemical Name: (2S)-2-Methoxy-1-propanol
• CAS No.: 1589-47-5
• Molecular Formula: C4H10 O2
• Molecular Weight: 90.1222
• Hs Code.: 2909499000
• European Community (EC) Number: 875-151-6
• UNII: DBP4G166FP
• DSSTox Substance ID: DTXSID70369954
• Nikkaji Number: J1.926.094A
• Wikidata: Q27276311
• Mol file: 1589-47-5.mol

Synonyms:2-Methoxy-1-hydroxypropane;2-Methoxy-1-propanol; 2-Methoxypropanol

Chemical Property of (2S)-2-Methoxy-1-propanol

Chemical Property:

• Melting Point: -84.2°C (estimate)
• Refractive Index: 1.4070
• Boiling Point: 130 °C at 760 mmHg
• PKA: 14.44±0.10(Predicted)
• Flash Point: 41.9 °C
• PSA: 29.46000
• Density: 0.912 g/cm³
• LogP: 0.01360
• Storage Temp.: 2-8°C
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 90.068079557
• Heavy Atom Count: 6
• Complexity: 28.7

Purity/Quality:

99% ^*data from raw suppliers

2-Methoxypropanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): A reproductive hazard.
• Hazard Codes: T
• Statements: 61-10-37/38-41
• Safety Statements: 53-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(CO)OC
• Isomeric SMILES: C[C@H](CO)OC

Technology Process of (2S)-2-Methoxy-1-propanol

There total 39 articles about (2S)-2-Methoxy-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

propene (187737-37-7,13987-01-4,15220-87-8,9003-07-0,676-63-1,25085-53-4) → propylene glycol (57-55-6,63625-56-9) + 1-methoxy-2-propanol (107-98-2) + 2-methoxypropanol (1589-47-5) + methyloxirane (75-56-9,16033-71-9)

Guidance literature:

With dihydrogen peroxide; titanium-silicate; In methanol; at 40 ℃;

Reference yield: 92.0%

methanol (67-56-1) + methyloxirane (75-56-9,16033-71-9) → 1-methoxy-2-propanol (107-98-2) + 2-methoxypropanol (1589-47-5)

Guidance literature:

With MCM-41-encapsulated cetyltrimethylammonium hydroxide; at 110 ℃; for 3h; regioselective reaction;

DOI:10.1080/00397911003707089

Reference yield: 79.0%

methanol (67-56-1) + (R)-propylene oxide (15448-47-2) → (R)-1-methoxy-2-propanol (4984-22-9) + 2-methoxypropanol (1589-47-5)

Guidance literature:

With sodium hydroxide; for 5h; Reflux;

DOI:10.1021/acs.oprd.7b00216

upstream raw materials:

1,1-dimethoxyethane

ethyl 2-methoxypropionate

methanol

methyloxirane

Downstream raw materials:

toluene-4-sulfonic acid 2-methoxy-2-methylethyl ester

dipropylene glycol dimethyl ether

dipropylene glycol dimethyl ether

racemic 2-methoxypropyl 4-methylbenzenesulphonate

Refernces

• 1、 Luo, Zhiqiang,Wang, Jun,He, Yanqing,Ao, Qiong,Deng, Qiang,Zeng, Zheling,Wang, Hongming,Deng, Shuguang. "A Stable Zn-Based Metal–Organic Framework as an Efficient Catalyst for Carbon Dioxide Cycloaddition and Alcoholysis at Mild Conditions". . p. 1408 - 1417. Retrieved 2020.
• 2、 Ballesteros–Soberanas, Jordi,Leyva–Pérez, Antonio,Martínez–Castelló, Aarón,Oliver–Meseguer, Judit,Tejeda–Serrano, María. "Nanotitania catalyzes the chemoselective hydration and alkoxylation of epoxides". . . Retrieved 2021/10/12.
• 3、 Rahmatpour, Ali,Sajjadinezhad, Seyed Mehrzad. "Cross-linked poly(N-vinylpyrrolidone)-titanium tetrachloride complex: A novel stable solid TiCl4 equivalent as a recyclable polymeric Lewis acid catalyst for regioselective ring-opening alcoholysis of epoxides". . . Retrieved 2021/08/09.