3-HYDROXY-5-METHYLPYRIDINE

Base Information

• Chemical Name: 3-HYDROXY-5-METHYLPYRIDINE
• CAS No.: 42732-49-0
• Molecular Formula: C6H7NO
• Molecular Weight: 109.128
• Hs Code.: 2933399990
• Mol file: 42732-49-0.mol

Synonyms:3-Pyridinol,5-methyl-;3-Hydroxy-5-methylpyridine;5-Methyl-3-pyridinol;NSC 13518;

Chemical Property of 3-HYDROXY-5-METHYLPYRIDINE

Chemical Property:

• Appearance/Colour: Light yellow cryst
• Vapor Pressure: 0.000209mmHg at 25°C
• Melting Point: 136-140℃
• Refractive Index: 1.55
• Boiling Point: 317.3 °C at 760 mmHg
• PKA: 9.27±0.10(Predicted)
• Flash Point: 145.7 °C
• PSA: 33.12000
• Density: 1.12 g/cm³
• LogP: 1.09560
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

99% ^*data from raw suppliers

5-Methylpyridin-3-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Hydroxy-5-methylpyridine is used to prepare 3-hydroxy-5-methyl-2-nitropyridine by nitration reaction.

Technology Process of 3-HYDROXY-5-METHYLPYRIDINE

There total 14 articles about 3-HYDROXY-5-METHYLPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

2-methyl-1-(1-tosyl-1H-1,2,3-triazol-4-yl)allyl acetate → 5-methyl-3-pyridinol (42732-49-0)

Guidance literature:

2-methyl-1-(1-tosyl-1H-1,2,3-triazol-4-yl)allyl acetate; With rhodium bis(1-adamantate) dimer; In toluene; at 50 ℃; for 4h; Inert atmosphere;

With potassium hydroxide; In tetrahydrofuran; methanol; at 70 ℃; for 0.5h;

With ammonium chloride; In tetrahydrofuran; methanol; water;

DOI:10.1039/c7cc02521a

Reference yield:

(5-hydroxy-[3]pyridyl)-acetic acid (100958-68-7) → 5-methyl-3-pyridinol (42732-49-0)

Guidance literature:

at 230 ℃;

DOI:10.1021/ja01512a057

Reference yield:

→ 5-methyl-3-pyridinol (42732-49-0)

Guidance literature:

With sodium hydroxide; water; at 240 ℃;

upstream raw materials:

(5-hydroxy-[3]pyridyl)-acetic acid

5-methylpyridin-3-yl 4-methylbenzenesulfonate

3-picoline-N-oxide

3-pyridinylacetonitrile

Refernces