Androst-4-en-3-one

Base Information

• Chemical Name: Androst-4-en-3-one
• CAS No.: 2872-90-4
• Molecular Formula: C19H28O
• Molecular Weight: 272.431
• Mol file: 2872-90-4.mol

Synonyms:3-oxo-adipic acid-6-ethyl ester-1-benzyl ester;1-Benzyl-6-ethyl-3-oxohexan-1,6-dioat;androsten-3-on;3-Oxo-adipinsaeure-6-aethylester-1-benzylester;Hexanedioic acid,3-oxo-,6-ethyl 1-(phenylmethyl) ester;3-oxoandrost-4-ene;androst-4-en-3-one;3-ketoandrost-4-ene;1-benzyl 6-ethyl 3-oxohexanedioate;4-androsten-3-one;

Chemical Property of Androst-4-en-3-one

Chemical Property:

• Boiling Point: 390.6°Cat760mmHg
• Flash Point: 180.6°C
• PSA: 17.07000
• Density: 1.05g/cm³
• LogP: 4.90840

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Androst-4-en-3-one

There total 24 articles about Androst-4-en-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

C19H27IO → 4-androsten-3-one (2872-90-4)

Guidance literature:

With bismuth(III) oxide; N-ethyl-N,N-diisopropylamine; para-thiocresol; In dichloromethane; for 3.5h; Irradiation;

Reference yield: 58.2%

androst-5-en-3β-ol (1476-64-8,25706-90-5) → 4-androsten-3-one (2872-90-4)

Guidance literature:

With cyclohexanone; aluminum isopropoxide; In toluene; Heating;

DOI:10.1007/BF00762056

Reference yield: 58.0%

androstan-3-one (1224-95-9,118371-41-8) → (5S,8S,9S,10S,13S,14S)-10,13-dimethyl-4,5,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one (3248-10-0) + 4-androsten-3-one (2872-90-4) + 3-ketoandrosta-1,4-diene (3090-99-1)

Guidance literature:

With toluene-4-sulfonic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,4-dioxane; for 96h; Ambient temperature;

DOI:10.1021/jo00245a013

upstream raw materials:

3a,6-dimethyl-dodecahydro-cyclopenta[a]naphthalen-7-one

diethyl ether

ethanol

diethyl-methyl-(3-oxo-butyl)-ammonium; iodide

Downstream raw materials:

5β-Androstan-3-on

androstan-3-one

5β-androstan-3-one

1.5-Cyclo-10α-androsten-(3)-on-(2)

Refernces

• 1、 -. "17-substituted steroids useful in cancer treatment". . . Retrieved 2008/06/13.
• 2、 Schneider, Gyula,Mesko, Eszter,Hackler, Laszlo,Dombi Gyoergy,Zeigan, Dieter,Engelhardt, Guenter. "Steroids. Part 32. Configurational Analysis of 16-Methyltestosterone Derivatives". . p. 1597 - 1600. Retrieved 2007/10/02.